ArticleNutrients2019
DNA Methylation Signatures of Breastfeeding in Buccal Cells Collected in Mid-Childhood.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Breastfeeding association with DNA methylation in the pregnancy and childhood epigenetics (PACE) consortium.Clinical epigenetics · 2026Pooled it
- DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts.Clinical epigenetics · 2021Pooled it
- Epigenome-Wide Association of Infant Feeding and Changes in DNA Methylation from Birth to 10 Years.Nutrients · 2020Trial
- Negative association between higher maternal pre-pregnancy body mass index and breastfeeding outcomes is not mediated by DNA methylation.Scientific reports · 2024Article
- Maternal outcomes related to Genetic and epigenetic Variation in the oxytocin system: A scoping review.Comprehensive psychoneuroendocrinology · 2023Article
- No association between war-related trauma or PTSD symptom severity and epigenome-wide DNA methylation in Burundian refugees.European journal of psychotraumatology · 2023Article
- A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits.Nature communications · 2022Article
- A systematic assessment of cell type deconvolution algorithms for DNA methylation data.Briefings in bioinformatics · 2022Article
- Is Aberrant DNA Methylation a Key Factor in Molar Incisor Hypomineralization?Current issues in molecular biology · 2022Article
- Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects.Biomedicines · 2022Review
- DNA methylation in relation to gestational age and brain dysmaturation in preterm infants.Brain communications · 2022Article
- Article
- Article
- Epigenome-Wide Association Study Reveals Duration of Breastfeeding Is Associated with Epigenetic Differences in Children.International journal of environmental research and public health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
Abstract
Breastfeeding has long-term benefits for children that may be mediated via the epigenome. This pathway has been hypothesized, but the number of empirical studies in humans is small and mostly done by using peripheral blood as the DNA source. We performed an epigenome-wide association study (EWAS) in buccal cells collected around age nine (mean = 9.5) from 1006 twins recruited by the Netherlands Twin Register (NTR). An age-stratified analysis examined if effects attenuate with age (median split at 10 years;
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.