ArticleNutrients2019
Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Ingestion ofNutrients · 2020Trial
- Soluble fermentable dietary fiber attenuates age-related cognitive impairment via neuroimmune and antioxidant modulation: evidence from multilevel analyses in populations and aging mouse models.Frontiers in immunology · 2026Article
- Gut microbiota in obesity management: from microbial clocks to precision microbial therapies.Frontiers in cellular and infection microbiology · 2026Review
- Effectiveness of personalized granola tailored to the gut microbiota for improving gut environment and mood states.Frontiers in microbiology · 2025Article
- Granola consumption with multiple prebiotics in Japanese participants increasesFrontiers in nutrition · 2025Article
- Effect of circadian clock and claudin regulations on inulin-induced calcium absorption in the mouse intestinal tract.Bioscience of microbiota, food and health · 2023Article
- Relationship between Fasting and Postprandial Glucose Levels and the Gut Microbiota.Metabolites · 2022Article
- Article
- Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure.Frontiers in nutrition · 2022Article
- Variations on gut health and energy metabolism in pigs and humans by intake of different dietary fibers.Food science & nutrition · 2021Review
- Prebiotic Food Intake May Improve Bone Resorption in Japanese Female Athletes: A Pilot Study.Sports (Basel, Switzerland) · 2021Article
- Nutrition, Microbiota and Noncommunicable Diseases.Nutrients · 2020Article
- Combinatorial Effects of Soluble, Insoluble, and Organic Extracts from Jerusalem Artichokes on Gut Microbiota in Mice.Microorganisms · 2020Article
- Effect of Dose and Timing of Burdock (Microorganisms · 2020Article
- Article
- The Timing Effects of Soy Protein Intake on Mice Gut Microbiota.Nutrients · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Water-soluble dietary fiber is known to modulate fecal microbiota. Although there are a few reports investigating the effects of fiber intake timing on metabolism, there are none on the effect of intake timing on microbiota. Therefore, in this study, we examined the timing effects of inulin-containing food on fecal microbiota. Mice were housed under conditions with a two-meals-per-day schedule, with a long fasting period in the morning and a short fasting period in the evening. Then, 10-14 days after inulin intake, cecal content and feces were collected, and cecal pH and short-chain fatty acids (SCFAs) were measured. The microbiome was determined using 16S rDNA sequencing. Inulin feeding in the morning rather than the evening decreased the cecal pH, increased SCFAs, and changed the microbiome composition. These data suggest that inulin is more easily digested by fecal microbiota during the active period than the inactive period. Furthermore, to confirm the effect of fasting length, mice were housed under a one-meal-per-day schedule. When the duration of fasting was equal, the difference between morning and evening nearly disappeared. Thus, our study demonstrates that consuming inulin at breakfast, which is generally after a longer fasting period, has a greater effect on the microbiota.
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