Evidence map›Paper›PMID 31744119›Full record

Trial reportNutrients2019

Sub-Chronic Consumption of Dark Chocolate Enhances Cognitive Function and Releases Nerve Growth Factors: A Parallel-Group Randomized Trial.

Eri Sumiyoshi, Kentaro Matsuzaki, Naotoshi Sugimoto, Yoko Tanabe, Toshiko Hara, Masanori Katakura, Mayumi Miyamoto, Seiji Mishima, Osamu Shido

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343611 (Combining Vitamin E-functionalized CHOcolate With Physical Exercise to Reduce the risK Of Protein Energy Malnutrition in Pre-dementia AGEd People), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05343611 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Combining Vitamin E-functionalized CHOcolate With Physical Exercise to Reduce the risK Of Protein Energy Malnutrition in Pre-dementia AGEd People

TypeinterventionalSponsorMassimo Venturelli, PhDRan2022 to 2024Enrolled102ConditionsDementia, Dementia, Mild, Dementia Moderate, Dementia SenileArmsCombination of High Protein Diet and Physical Exercise protocol, HPP Choko, HPP/VE Choko
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Bedtime banana and milk intake on sleep and biochemical parameters.Asia Pacific journal of clinical nutrition · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
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  18. Article
  19. Chocolate, "Food of the Gods": History, Science, and Human Health.International journal of environmental research and public health · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Eri SumiyoshiDepartment of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0000-0003-4871-3934
Kentaro MatsuzakiDepartment of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0000-0002-5942-8840
Naotoshi SugimotoDepartment of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.ORCID 0000-0003-1995-5002
Yoko TanabeDepartment of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Toshiko HaraDepartment of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Masanori KatakuraDepartment of Nutritional Physiology, Faculty of Pharmaceutical Sciences, Josai University, Sakado 350-0295, Japan.ORCID 0000-0002-2237-9651
Mayumi MiyamotoSchool of Nursing, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Seiji MishimaCentral Clinical Laboratory, Shimane University Hospital, Izumo 693-8501, Japan.
Osamu ShidoDepartment of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan.
Shimane University · JPJosai University · JPKanazawa University · JPShimane University Hospital · JP

Funding

Japan Society for the Promotion of Science 17H01963
6 · The paper itself

Abstract

Previous research has shown that habitual chocolate intake is related to cognitive performance and that frequent chocolate consumption is significantly associated with improved memory. However, little is known about the effects of the subchronic consumption of dark chocolate (DC) on cognitive function and neurotrophins. Eighteen healthy young subjects (both sexes; 20-31 years old) were randomly divided into two groups: a DC intake group (

Indexed as

ChocolateCognitionAdultBrain-Derived Neurotrophic FactorCerebrovascular CirculationEatingFemaleHealthy VolunteersHumansMaleNerve Growth FactorNerve Growth FactorsStroop TestTheobromineYoung AdultBrain-Derived Neurotrophic FactorNerve Growth FactorNerve Growth FactorsTheobrominecognitive functiondark chocolatedigital cancellation testnerve growth factorStroop color word testsubchronic effecttheobromineyoung-adult

Identifiers

PMID31744119
PMCPMC6893800
OpenAlexW2984985650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.