Evidence map›Paper›PMID 31743962›Full record

ReviewAllergy, asthma & immunology research2020

Critical Points on the Use of Biologicals in Allergic Diseases and Asthma.

Ioana Agache, Catalina Cojanu, Alexandru Laculiceanu, Liliana Rogozea

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Allergy, asthma & immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05009758 (Moving Towards PREcision Medicine In United Airways Disease), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05009758 narecruitingnot on this mapstarted 2021, after this paper: background citation

Moving Towards PREcision Medicine In United Airways Disease: Unraveling inflaMmatory Patterns in Asthmatic Patients With or Without Nasal Polyps (PREMIUM) - a Descriptive Pilot Study

TypeinterventionalSponsorMedical University of ViennaRan2021 to 2026Enrolled30ConditionsAsthma, Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis), Nasal PolypsArmsBlood sampling, Nasosorption, Oral sampling, Bronchoscopy, Nasal biopsy
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Eosinophilic-Associated Disease Overlap: What Do We Know About It?Allergy, asthma & immunology research · 2023
    Article
  3. Roles of Tissue Inhibitor of Metalloproteinase-1 in Severe Asthma.Allergy, asthma & immunology research · 2023
    Article
  4. Review
  5. Review
  6. From Emollients to Biologicals: Targeting Atopic Dermatitis.International journal of molecular sciences · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Pulmonary Surfactants: a New Therapeutic Target in Asthma.Current allergy and asthma reports · 2020
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ioana AgacheDepartment of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania. ibrumaru@unitbv.ro.ORCID https://orcid.org/0000-0001-7994-364X
Catalina CojanuDepartment of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.
Alexandru LaculiceanuDepartment of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.
Liliana RogozeaDepartment of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.ORCID https://orcid.org/0000-0001-9551-9910
Transylvania University of Brașov · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improved understanding of the contribution of immune-inflammatory mechanisms in allergic diseases and asthma has encouraged development of biologicals and small molecules specifically targeting the innate and adaptive immune response. There are several critical points impacting the efficacy of this stratified approach, from the complexity of disease endotypes to the effectiveness in real-world settings. We discuss here how these barriers can be overcome to facilitate the development of implementation science for allergic diseases and asthma.

Indexed as

asthmaBiological productshypersensitivityphenotype, precision medicine

Identifiers

PMID31743962
PMCPMC6875478
OpenAlexW2984566094

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.