ArticleJournal of the American Medical Informatics Association : JAMIA2020
Evaluating a digital sepsis alert in a London multisite hospital network: a natural experiment using electronic health record data.
Article in Journal of the American Medical Informatics Association : JAMIA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Sepsis Alert Systems, Mortality, and Adherence in Emergency Departments: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Artificial intelligence for improving decision-making in bacterial infection management: a narrative review.The Journal of antimicrobial chemotherapy · 2026Review
- Digital Health Technologies and Standardized Protocols for Patient Safety in Hospital-Based Settings: A Scoping Review.Journal of multidisciplinary healthcare · 2026Review
- Adipose-derived mesenchymal stem cell-derived extracellular vesicles carry microRNA-214-3p to target GSTZ1 to curb ferroptosis in lung epithelial cells during sepsis.Cytotechnology · 2025Article
- Digital innovation in healthcare: quantifying the impact of digital sepsis screening tools on patient outcomes-a multi-site natural experiment.BMJ health & care informatics · 2025Article
- Blood RNA biomarkers and a point-of-care elastase assay for detecting host immune activation in suspected sepsis: Trajectory matters.PloS one · 2025Article
- The sepsis journey and where digital alerts can help: a qualitative, interview study with survivors and family members in England.Frontiers in public health · 2025Observational
- Views and Uses of Sepsis Digital Alerts in National Health Service Trusts in England: Qualitative Study With Health Care Professionals.JMIR human factors · 2024Article
- Information displays for automated surveillance algorithms of in-hospital patient deterioration: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2023Article
- Epic Sepsis Model Inpatient Predictive Analytic Tool: A Validation Study.Critical care explorations · 2023Article
- Prevalence of electronic screening for sepsis in National Health Service acute hospitals in England.BMJ health & care informatics · 2023Article
- Personalization: a new political arithmetic?Distinktion : Scandinavian journal of social theory · 2023Article
- The impact of changes in coding on mortality reports using the example of sepsis.BMC medical informatics and decision making · 2022Article
- Effectiveness of automated alerting system compared to usual care for the management of sepsis.NPJ digital medicine · 2022Article
- ICU Cockpit: a platform for collecting multimodal waveform data, AI-based computational disease modeling and real-time decision support in the intensive care unit.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Wearable Photoplethysmography for Cardiovascular Monitoring.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2022Article
- Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Adult Inpatients: Scoping Review.Journal of medical Internet research · 2022Article
- Challenges and recommendations for high quality research using electronic health records.Frontiers in digital health · 2022Article
- Developing useful early warning and prognostic scores for COVID-19.Postgraduate medical journal · 2021Article
- Puerarin Inhibits Ferroptosis and Inflammation of Lung Injury Caused by Sepsis in LPS Induced Lung Epithelial Cells.Frontiers in pediatrics · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe study sought to determine the impact of a digital sepsis alert on patient outcomes in a UK multisite hospital network. MATERIALS AND
methodsA natural experiment utilizing the phased introduction (without randomization) of a digital sepsis alert into a multisite hospital network. Sepsis alerts were either visible to clinicians (patients in the intervention group) or running silently and not visible (the control group). Inverse probability of treatment-weighted multivariable logistic regression was used to estimate the effect of the intervention on individual patient outcomes. OUTCOMES: In-hospital 30-day mortality (all inpatients), prolonged hospital stay (≥7 days) and timely antibiotics (≤60 minutes of the alert) for patients who alerted in the emergency department.
resultsThe introduction of the alert was associated with lower odds of death (odds ratio, 0.76; 95% confidence interval [CI], 0.70-0.84; n = 21 183), lower odds of prolonged hospital stay ≥7 days (OR, 0.93; 95% CI, 0.88-0.99; n = 9988), and in patients who required antibiotics, an increased odds of receiving timely antibiotics (OR, 1.71; 95% CI, 1.57-1.87; n = 4622). DISCUSSION: Current evidence that digital sepsis alerts are effective is mixed. In this large UK study, a digital sepsis alert has been shown to be associated with improved outcomes, including timely antibiotics. It is not known whether the presence of alerting is responsible for improved outcomes or whether the alert acted as a useful driver for quality improvement initiatives.
conclusionsThese findings strongly suggest that the introduction of a network-wide digital sepsis alert is associated with improvements in patient outcomes, demonstrating that digital based interventions can be successfully introduced and readily evaluated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.