ArticleNeuroImage2020
The effects of age on reward magnitude processing in the monetary incentive delay task.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task.NeuroImage · 2022Pooled it
- Pooled it
- The functional neuroanatomy of event-based and time-based prospective memory, and its improvement.Communications biology · 2026Trial
- Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour.Nature communications · 2025Trial
- Effects of the Fyn kinase inhibitor saracatinib on ventral striatal activity during performance of an fMRI monetary incentive delay task in individuals family history positive or negative for alcohol use disorder. A pilot randomised trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- A neurodevelopmental model of eating disorder risk in midlife to older adulthood.Neuroscience and biobehavioral reviews · 2026Review
- Neurostructural Correlates and Impulsive Mechanisms of Exercise Dependence in Middle-Aged and Elderly Adults: Evidence from Gray Matter and Structural Covariance Networks.Brain topography · 2026Article
- Sex differences in resting-state hypothalamic connectivity and its relationship with negative emotion and behavior measures in young adults.Brain structure & function · 2026Article
- The dynamics of explore-exploit decisions suggest a threshold mechanism for reduced random exploration in older adults.PLoS computational biology · 2025Article
- Greater fatigue is more strongly associated with reduced reward sensitivity in the long-term phase of coronavirus disease (COVID-19) than in the early phase.Brain, behavior, & immunity - health · 2025Article
- Food Inhibitory Control and Reward Responsiveness in Healthy Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Article
- Neurophysiological characteristics of reward processing in deaf college students under different social contexts.Frontiers in neuroscience · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study.Quantitative imaging in medicine and surgery · 2024Article
- Sleep Deficits Inter-Link Lower Basal Forebrain-Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men.The international journal of neuropsychopharmacology · 2023Article
- The effect of loss incentives on prospective memory in healthy older adults: study protocol of a randomized controlled trial using ultra-high field fMRI.BMC psychiatry · 2023Article
- Hyperthymic temperament predicts neural responsiveness for nonmonetary reward.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers.Addiction neuroscience · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Previous studies have suggested age-related differences in reward-directed behavior and cerebral processes in support of the age effects. However, it remains unclear how age may influence the processing of reward magnitude. Here, with 54 volunteers (22-74 years of age) participating in the Monetary Incentive Delay Task (MIDT) with explicit cues ($1, ¢1, or nil) and timed response to win, we characterized brain activations during anticipation and feedback and the effects of age on these regional activations. Behaviorally, age was associated with less reaction time (RT) difference between dollar and cent trials, as a result of slower response to the dollar trials; i.e., age was positively correlated with RT dollar - RT cent, with RT nil as a covariate. Both age and the RT difference ($1 - ¢1) were correlated with diminished activation of the right caudate head, right anterior insula, supplementary motor area (SMA)/pre-SMA, visual cortex, parahippocampal gyrus, right superior/middle frontal gyri, and left primary motor cortex during anticipation of $1 vs. ¢1 reward. Further, these regional activities mediated the age effects on RT differences. In responses to outcomes, age was associated with decreases in regional activations to dollar vs. cent loss but only because of higher age-related responses to cent losses. Together, these findings suggest age-related differences in sensitivity to the magnitude of reward. With lower cerebral responses during anticipation to win large rewards and higher responses to outcomes of small loss, aging incurs a constricted sensitivity to the magnitude of reward.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.