ArticleAngewandte Chemie (International ed. in English)2020
Manganese-Catalyzed β-Methylation of Alcohols by Methanol.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 116 citations in OpenAlex.
- A universal atomically dispersed cobalt catalyst for alkylation of ketones alcohols and lignin-derived compounds.Nature communications · 2026Article
- Single-Step Synthesis of 1,2-Cyclopentanediones by Dehydrogenative Annulation of Ethylene Glycol with Secondary Alcohols.Journal of the American Chemical Society · 2025Article
- Manganese-catalyzed cyclopropanation of allylic alcohols with sulfones.Nature communications · 2024Article
- Diazines and Triazines as Building Blocks in Ligands for Metal-Mediated Catalytic Transformations.ACS organic & inorganic Au · 2024Review
- Manganese-catalyzed C-C and C-N bond formation with alcohols via borrowing hydrogen or hydrogen auto-transfer.Beilstein journal of organic chemistry · 2024Review
- Rational design of N-heterocyclic compound classes via regenerative cyclization of diamines.Nature communications · 2023Article
- Manganese Promoted (Bi)carbonate Hydrogenation and Formate Dehydrogenation: Toward a Circular Carbon and Hydrogen Economy.ACS central science · 2022Article
- Basic Promotors Impact Thermodynamics and Catalyst Speciation in Homogeneous Carbonyl Hydrogenation.Journal of the American Chemical Society · 2022Article
- Rhoda-Electrocatalyzed C-H Methylation and Paired Electrocatalyzed C-H Ethylation and Propylation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Acceptorless Dehydrogenation of Methanol to Carbon Monoxide and Hydrogen using Molecular Catalysts.Angewandte Chemie (International ed. in English) · 2021Article
- Carbon Dioxide Hydrogenation to Formate Catalyzed by a Bench-Stable, Non-Pincer-Type Mn(I) Alkylcarbonyl Complex.Organometallics · 2021Article
- Borrowing Hydrogen for Organic Synthesis.ACS central science · 2021Review
- Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation.Chemical science · 2020Article
- Manganese-Catalyzed β-Methylation of Alcohols by Methanol.Angewandte Chemie (International ed. in English) · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We report an earth-abundant-metal-catalyzed double and single methylation of alcohols. A manganese catalyst, which operates at low catalyst loadings and short reaction times, mediates these reactions efficiently. A broad scope of primary and secondary alcohols, including purely aliphatic examples, and 1,2-aminoalcohols can be methylated. Furthermore, alcohol methylation for the synthesis of pharmaceuticals has been demonstrated. The catalyst system tolerates many functional groups among them hydrogenation-sensitive examples and upscaling is easily achieved. Mechanistic investigations are indicative of a borrowing hydrogen or hydrogen autotransfer mechanism involving a bimetallic K-Mn catalyst. The catalyst accepts hydrogen as a proton and a hydride from alcohols efficiently and reacts with a chalcone via hydride transfer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.