ArticleJournal of clinical laboratory analysis2020
The RAS-PI3K-AKT-NF-κB pathway transcriptionally regulates the expression of BCL2 family and IAP family genes and inhibits apoptosis in fibrous epulis.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- [Exploring the mechanism of action ofSe pu = Chinese journal of chromatography · 2026Article
- Reduced expression of BIRC2 and BIRC3 associated with longer survival in pediatric high-grade gliomas.Scientific reports · 2026Article
- Natural Products Targeting Key Molecular Hallmarks in Gastric Cancer: Focus on Apoptosis, Inflammation, and Chemoresistance.International journal of molecular sciences · 2026Review
- PI3K over-expression drives canine mammary tumor progression.Frontiers in veterinary science · 2026Article
- Nidogen 1-enriched extracellular vesicles promote liver metastasis by inducing EMT and activating stellate cells.iScience · 2025Article
- Epulis: A Narrative Review of Epidemiology, Clinical Features, Pathogenesis, and Management.Oral health & preventive dentistry · 2025Review
- The Bidirectional Interaction Between NF-Journal of immunology research · 2025Review
- Network pharmacological analysis and experimental study of melatonin in chronic prostatitis/chronic pelvic pain syndrome.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- A large-cohort study of 2971 cases of epulis: focusing on risk factors associated with recurrence.BMC oral health · 2023Article
- BRD7 inhibits enhancer activity and expression of BIRC2 to suppress tumor growth and metastasis in nasopharyngeal carcinoma.Cell death & disease · 2023Article
- Article
- PCR array analysis identified hyperproliferation but not autophagy or apoptosis in fibrous epulis.Journal of clinical laboratory analysis · 2021Article
- Emerging role of RNA modification N6-methyladenosine in immune evasion.Cell death & disease · 2021Review
- BCL2 enhances survival of porcine pluripotent stem cells through promoting FGFR2.Cell proliferation · 2021Article
- The RAS-PI3K-AKT-NF-κB pathway transcriptionally regulates the expression of BCL2 family and IAP family genes and inhibits apoptosis in fibrous epulis.Journal of clinical laboratory analysis · 2020Article
- Tribuloside: Mechanisms and Efficacy in Treating Acute Lung Injury Revealed by Network Pharmacology and Experimental Validation.Dose-response : a publication of International Hormesis SocietyArticle
- Role and Mechanism of Astragalus Monomer Quercetin in Modulating Akt/Bcl-2 Pathway to Improve Ventricular Remodeling in Chronic Heart Failure.International journal of applied & basic medical researchArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEpulis has a tumor-like appearance but is considered to be a massive reactive lesion rather than a true neoplasia. Limited information about the pathogenesis of epulis is available. The purpose of our study was to identify potential signaling pathways in fibrous epulis through transcriptome profiling.
methodsDifferentially expressed genes (DEGs) between fibrous epulis lesions and normal gingival tissues were detected using RNA sequencing (RNAseq). The expression levels of eighteen genes were validated using quantitative real-time PCR (qRT-PCR).
resultsRNAseq identified 533 upregulated genes and 732 downregulated genes. The top 10 upregulated genes were IL11, OSM, MMP3, KRT75, MMP1, IL6, IL1B, IL24, SP7, and ADGRG3. The top 10 downregulated genes were BCHE, TYR, DCT, KRT222, RP11-507K12.1, COL6A5, PMP2, GFRA1, SCN7A, and CDH19. KEGG pathway analysis further indicated that the DEGs were enriched in "Pathways in cancer" and the "Ras signaling pathway". quantitative real-time PCR verified that the expression levels of SOS1, HRAS, PIK3CA, AKT3, IKBKA, IKBKB, NFKB1, BCL2, BCL2L1, XIAP, BIRC2, and BIRC3 were increased significantly.
conclusionsThe current transcriptomic profiling study reveals that in fibrous epulis, RAS-PI3K-AKT-NF-κB pathway transcriptionally regulates the expression of BCL2 family and IAP family genes, leading to increased proliferation and apoptosis inhibition.
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Registered trials
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