Evidence map›Paper›PMID 31743514›Full record

ArticleCancer science2020

Antitumor activity of cyclin-dependent kinase inhibitor alsterpaullone in Epstein-Barr virus-associated lymphoproliferative disorders.

Takahiro Watanabe, Yoshitaka Sato, H M Abdullah Al Masud, Masahiro Takayama, Hiroki Matsuda, Yuya Hara, Yusuke Yanagi, Masahiro Yoshida, Fumi Goshima, Takayuki Murata and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Takahiro WatanabeDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-7249-8106
Yoshitaka SatoDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-8541-6413
H M Abdullah Al MasudDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0002-0953-2471
Masahiro TakayamaDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroki MatsudaDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuya HaraDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yusuke YanagiDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Masahiro YoshidaDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Fumi GoshimaDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takayuki MurataDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroshi KimuraDepartment of Virology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID https://orcid.org/0000-0001-8063-5660
Nagoya University · JPFujita Health University · JP

Funding

GSK JapanHori Sciences and Arts FoundationJapan Society for the Promotion of Science 17H04081Japan Society for the Promotion of Science JP16H06231Japan Society for the Promotion of Science JP16H06867
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) is a well-established tumor virus that has been implicated in a wide range of immunodeficiency-associated lymphoproliferative disorders (LPDs). Although rituximab, a CD20 mAb, has proven effective against EBV-associated LPDs, prolonged use of this drug could lead to resistance due to the selective expansion of CD20

Indexed as

AnimalsAntineoplastic AgentsApoptosisBenzazepinesCell Cycle CheckpointsCell LineCyclin-Dependent Kinase 2Epstein-Barr Virus InfectionsG1 PhaseHEK293 CellsHerpesvirus 4, HumanHumansIndolesLymphoproliferative DisordersMiceMice, Inbred NODalsterpaulloneAntineoplastic AgentsBenzazepinesCyclin-Dependent Kinase 2IndolesProtein Kinase InhibitorsCDKEBVLPDrituximabvPIC

Identifiers

PMID31743514
PMCPMC6942432
OpenAlexW2990759898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.