ArticleAngewandte Chemie (International ed. in English)2020
Copper-Catalyzed Enantioselective Allylic Alkylation with a γ-Butyrolactone-Derived Silyl Ketene Acetal.
Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Copper-catalyzed asymmetric allylic substitution of racemic/Chemical science · 2024Review
- Palladium-catalyzed asymmetric allylic alkylation (AAA) with alkyl sulfones as nucleophiles.Chemical science · 2021Article
- Silver Catalyzed Decarbonylative [3 + 2] Cycloaddition of Cyclobutenediones and Formamides.Molecules (Basel, Switzerland) · 2021Article
- CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes: Toward Carboxylic Acids with Acyclic Quaternary Centers.Journal of the American Chemical Society · 2021Article
- Enantioselective synthesis of highly oxygenated acyclic quaternary center-containing building blocksChemical science · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Herein, we report a Cu-catalyzed enantioselective allylic alkylation using a γ-butyrolactone-derived silyl ketene acetal. Critical to the development of this work was the identification of a novel mono-picolinamide ligand with the appropriate steric and electronic properties to afford the desired products in high yield (up to 96 %) and high ee (up to 95 %). Aryl, aliphatic, and unsubstituted allylic chlorides bearing a broad range of functionality are well-tolerated. Spectroscopic studies reveal that a Cu
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Registered trials
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