Evidence map›Paper›PMID 31742803›Full record

ArticleAngewandte Chemie (International ed. in English)2020

Cobalt(III)-Catalyzed C-H Amidation of Dehydroalanine for the Site-Selective Structural Diversification of Thiostrepton.

Ryan J Scamp, Edward deRamon, Eric K Paulson, Scott J Miller, Jonathan A Ellman

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Cobalt-catalyzed alkyne silylamidation unlocksNational science review · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan J ScampDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.
Edward deRamonDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.
Eric K PaulsonDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.
Scott J MillerDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.
Jonathan A EllmanDepartment of Chemistry, Yale University, 225 Prospect St., New Haven, CT, 06520, USA.ORCID 0000-0001-9320-5512

Funding

Next-generation C-H functionalization methods for organic synthesis and their applications to biological inquiryR35GM122473 · NIGMS · YALE UNIVERSITY · PI JONATHAN A ELLMAN · 2017 to 2026
$7.6M
Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026
$6.3M
NIGMS NIH HHS R35 GM122473NIGMS NIH HHS R35 GM132092
6 · The paper itself

Abstract

Thiostrepton is a potent antibiotic against a broad range of Gram-positive bacteria, but its medical applications have been limited by its poor aqueous solubility. In this work, the first C(sp

Indexed as

AlanineAnti-Bacterial AgentsCatalysisCobaltHumansThiostreptonAlanineAnti-Bacterial AgentsCobaltdehydroalanineThiostreptonantibioticsC−H activationchemoselectivitycobaltnatural products

Identifiers

PMID31742803
PMCPMC6940514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.