Evidence map›Paper›PMID 31742552›Full record

ArticleeLife2019

Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth.

Ryan T Willett, N Sumru Bayin, Andrew S Lee, Anjana Krishnamurthy, Alexandre Wojcinski, Zhimin Lao, Daniel Stephen, Alberto Rosello-Diez, Katherine L Dauber-Decker, Grant D Orvis and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  7. Review
  8. Article
  9. Cerebellar Functions Beyond Movement and Learning.Annual review of neuroscience · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Effects of progesterone on T-type-CaNeural regeneration research · 2022
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Ryan T Willett *Developmental Biology Program, Sloan Kettering Institute, New York, United States.
N Sumru Bayin *Developmental Biology Program, Sloan Kettering Institute, New York, United States.ORCID 0000-0003-4371-855X
Andrew S Lee *Developmental Biology Program, Sloan Kettering Institute, New York, United States.
Anjana Krishnamurthy *Developmental Biology Program, Sloan Kettering Institute, New York, United States.ORCID 0000-0002-4584-1722
Alexandre Wojcinski *Developmental Biology Program, Sloan Kettering Institute, New York, United States.
Zhimin LaoDevelopmental Biology Program, Sloan Kettering Institute, New York, United States.
Daniel StephenDevelopmental Biology Program, Sloan Kettering Institute, New York, United States.
Alberto Rosello-DiezDevelopmental Biology Program, Sloan Kettering Institute, New York, United States.
Katherine L Dauber-DeckerDevelopmental Biology Program, Sloan Kettering Institute, New York, United States.
Grant D OrvisDevelopmental Biology Program, Sloan Kettering Institute, New York, United States.
Zhuhao WuThe Laboratory of Brain Development and Repair, The Rockefeller University, New York, United States.ORCID 0000-0002-2471-0555
Marc Tessier-LavigneThe Laboratory of Brain Development and Repair, The Rockefeller University, New York, United States.
Alexandra L JoynerDevelopmental Biology Program, Sloan Kettering Institute, New York, United States.ORCID 0000-0001-7090-9605
Kettering University · USCornell University · USRockefeller University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Engrailed genes and cerebellum morphology, spatial gene expression and circuitryR37MH085726 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2014 to 2023
$6.7M
Signaling Pathways that Regulate Scaling and Regeneration of the CerebellumR01NS092096 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2015 to 2024
$4.8M
Roles of engrailed proteins in granule cells during cerebellum developmentF32NS080422 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI WILLETT, RYAN TERRENCE · 2012 to 2014
$150k
NCI NIH HHS P30 CA008748NCI NIH HHS P30CA008748-48NIMH NIH HHS R37 MH085726NIMH NIH HHS R37MH085726NINDS NIH HHS F32 NS080422NINDS NIH HHS F32NS080422NINDS NIH HHS R01 NS092096NINDS NIH HHS R01NS092096
6 · The paper itself

Abstract

For neural systems to function effectively, the numbers of each cell type must be proportioned properly during development. We found that conditional knockout of the mouse homeobox genes

Indexed as

Cell ProliferationAnimalsCerebellar CortexCerebellar NucleiEngrailed 2 ProteinGene Knockout TechniquesHomeodomain ProteinsMiceNerve Tissue ProteinsPurkinje CellsEn1 protein, mouseEngrailed 2 ProteinHomeodomain ProteinsNerve Tissue Proteinsconditional mutantsdevelopmental biologyengrailed genesgranule cellsinterneuronsmouseneuroscienceSHH

Identifiers

PMID31742552
PMCPMC6890462
OpenAlexW2990677723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.