ArticleEmerging infectious diseases2019
High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014-2016.
Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antimicrobial resistance inEpidemiology and infection · 2026Pooled it
- Global phylogenomics of Bordetella pertussis ST2 reveals regional heterogeneity in China and lineage-specific genome evolution.BMC genomics · 2026Article
- Co-infection with macrolide-resistant and macrolide-susceptibleASM case reports · 2026Article
- Laboratory diagnosis of pertussis: A survey on provincial public health laboratory methods.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2026Article
- Review
- Genome-wide association studies builds a predictive model and reveals novel resistance features for macrolide-resistant Bordetella pertussis.The Journal of antimicrobial chemotherapy · 2026Article
- Epidemiological and clinical characteristics of macrolide-resistant Bordetella pertussis in southern China: an 8-year retrospective study.BMC infectious diseases · 2026Article
- A retrospective, single-center analysis of clinical features and mortality risk factors in pediatric pertussis patients with severe pneumonia and encephalopathy complications in Southwest China.Italian journal of pediatrics · 2026Article
- Risk factors for pneumonia in children withOpen medicine (Warsaw, Poland) · 2026Article
- Parent-driven transmission, off-label SMZ-TMP, and severe pertussis prediction in infants under 2 months: a real-world observational cohort of 527 cases.Frontiers in pediatrics · 2026Article
- Genomic surveillance reveals global spread of macrolide-resistantJournal of clinical microbiology · 2025Article
- Genomic epidemiology and evolution ofEmerging microbes & infections · 2025Article
- Sharp rise in high-virulence Bordetella pertussis with macrolides resistance in Northern China.Emerging microbes & infections · 2025Article
- Pertussis-A Re-Emerging Threat Despite Immunization: An Analysis of Vaccine Effectiveness and Antibiotic Resistance.International journal of molecular sciences · 2025Review
- Molecular epidemiology and increasing macrolide resistance of Bordetella pertussis isolates in Guangzhou, China.BMC infectious diseases · 2025Article
- Pertussis risk assessment in children: a retrospective study of blood parameters from two medical centers.BMC infectious diseases · 2025Observational
- Molecular epidemiology and genomic features of Bordetella pertussis in Tianjin, China, 2023.BMC microbiology · 2025Article
- Macrolide-ResistantMicroorganisms · 2025Article
- Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species.Microbiology and immunology · 2025Article
- Population-based active surveillance of pertussis hospitalization rates in two cities of China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the government of China, reported cases of pertussis have increased remarkably and are still increasing. To determine the genetic relatedness of Bordetella pertussis strains, we compared multilocus variable-number tandem-repeat analysis (MLVA) results for isolates from China with those from Western countries. Among 335 isolates from China, the most common virulence-associated genotype was ptxA1/ptxC1/ptxP1/prn1/fim2-1/fim3A/tcfA2, which was more frequent among isolates from northern than southern China. Isolates of this genotype were highly resistant to erythromycin. We identified 36 ptxP3 strains mainly harboring ptxA1 and prn2 (35/36); ptxP3 strains were sensitive to erythromycin and were less frequently from northern China. For all isolates, the sulfamethoxazole/trimethoprim MIC was low, indicating that this drug should be recommended for patients infected with erythromycin-resistant B. pertussis. MLVA of 150 clinical isolates identified 13 MLVA types, including 3 predominant types. Our results show that isolates circulating in China differ from those in Western countries.
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