Evidence map›Paper›PMID 31742390›Full record

ArticleBiochemistry2019

Small Molecule Rescue and Glycosidic Conformational Analysis of the Twister Ribozyme.

Kyle J Messina, Ryszard Kierzek, Matthew A Tracey, Philip C Bevilacqua

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Investigation of the pThe journal of physical chemistry. B · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kyle J MessinaDepartment of Chemistry , The Pennsylvania State University , University Park , Pennsylvania 16802 , United States.
Ryszard KierzekInstitute of Bioorganic Chemistry , Polish Academy of Sciences , Noskowskiego 12/14 , 61-704 Poznan , Poland.
Matthew A TraceyDepartment of Biochemistry and Molecular Biology , The Pennsylvania State University , University Park , Pennsylvania 16802 , United States.
Philip C BevilacquaDepartment of Chemistry , The Pennsylvania State University , University Park , Pennsylvania 16802 , United States.ORCID 0000-0001-8074-3434
Pennsylvania State University · USInstitute of Bioorganic Chemistry, Polish Academy of Sciences · PL

Funding

RNA folding and catalysis at the interface of biophysics and genomicsR35GM127064 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PHILIP C BEVILACQUA · 2018 to 2026
$3.4M
NIGMS NIH HHS R35 GM127064
6 · The paper itself

Abstract

The number of self-cleaving ribozymes has increased sharply in recent years, giving rise to elaborations of the four known ribozyme catalytic strategies, α, β, γ, and δ. One such extension is utilized by the twister ribozyme, which is hypothesized to conduct δ, or general acid catalysis, via N3 of the

Indexed as

CatalysisGlycosidesHydrogen-Ion ConcentrationKineticsModels, MolecularRNA, CatalyticGlycosidesRNA, Catalytic

Identifiers

PMID31742390
PMCPMC6901379
OpenAlexW2989847829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.