ArticleNature metabolism2019
The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4.
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Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
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Who cites it
42 citing papers in PubMed, 64 citations in OpenAlex.
- Lipid droplet-associated proteins: Roles in cardiovascular diseases.Journal of lipid research · 2026Review
- Cardiac epigenome in heart development and disease.Nature reviews. Cardiology · 2026Review
- Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review).International journal of molecular medicine · 2026Review
- Patatin-domain-containing (phospho)lipases under control: Mammalian co-regulators and pathogenic activation mechanisms.FEBS open bio · 2026Review
- Metabo-epigenetic circuits of heart failure: chromatin-modifying enzymes as determinants of metabolic plasticity.EMBO molecular medicine · 2026Review
- Seipin-Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- HDAC4 Promotes Neuroprotection of Retinal Ganglion Cells After Optic Nerve Injury.Investigative ophthalmology & visual science · 2025Article
- Decoding the Lipid Droplet Proteome: New Frontiers in Cardiovascular Disease Research.International journal of molecular sciences · 2025Review
- Large Numbers of New Human Paralogs Discovered.bioRxiv : the preprint server for biology · 2025Article
- Histone deacetylase 4: A therapeutic target for cardiovascular diseases (Review).International journal of molecular medicine · 2025Review
- AAV9-mediated gene supplementation therapy prevents and rescues arrhythmogenic cardiomyopathy in Pnpla2-mutated mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Defective targeting of PNPLA1 to lipid droplets causes ichthyosis in ABHD5-syndromic epidermal differentiation disorder.Journal of lipid research · 2025Article
- Identification of lipid metabolism-related genes in myocardial infarction: implications for diagnosis and therapy.Journal of cardiothoracic surgery · 2025Article
- Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting.bioRxiv : the preprint server for biology · 2025Article
- ABHD8 antagonizes inflammation by facilitating chaperone-mediated autophagy-mediated degradation of NLRP3.Autophagy · 2025Article
- Unmasking crucial residues in adipose triglyceride lipase for coactivation with comparative gene identification-58.Journal of lipid research · 2024Article
- Identification of transcription factor-lipid droplet-related gene biomarkers for the prognosis of post-acute myocardial infarction-induced heart failure.Frontiers in cardiovascular medicine · 2024Article
- Epigenetic Regulation of Fibroblasts and Crosstalk between Cardiomyocytes and Non-Myocyte Cells in Cardiac Fibrosis.Biomolecules · 2023Review
- Histone Deacetylases: Molecular Mechanisms and Therapeutic Implications for Muscular Dystrophies.International journal of molecular sciences · 2023Review
- Fat-to-heart crosstalk in health and disease.Frontiers in genetics · 2023Review
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Authors and funding
24 authors at 8 institutions in 4 countries.
Zegeye H JebessaInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Kumar D ShanmukhaInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Matthias DewenterInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Lorenz H LehmannInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Chang XuInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Friederike SchreiterInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Dominik SiedeInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Xue-Min GongInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Barbara C WorstInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Giuseppina FedericoDepartment of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.
Sven W SauerDepartment of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany.
Tamas FischerJohn Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID http://orcid.org/0000-0002-7996-4042
Lisa WechselbergerInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Oliver J MüllerDepartment of Internal Medicine III, University of Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0001-8223-2638
Samuel SossallaDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Christoph DieterichDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Patrick MostDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Herrmann-Josef GröneDepartment of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.
Cedric MoroINSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
Monika ObererInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Guenter HaemmerleInstitute of Molecular Biosciences, University of Graz, Graz, Austria.
Hugo A KatusDZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Heidelberg, Germany.
Jens TyedmersInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany.
Johannes BacksInstitute of Experimental Cardiology, University of Heidelberg, Heidelberg, Germany. johannes.backs@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-2322-2699
Heidelberg University · DEUniversity of Graz · ATAustralian National University · AUChristian-Albrechts-Universität zu Kiel · DEGerman Cancer Research Center · DEInserm · FRPhilipps University of Marburg · DEUniversity Hospital Regensburg · DE
Funding
Austrian Science Fund FWF F 7303Austrian Science Fund FWF P 24857
Abstract
Catecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Here, we unmask a yet unrecognized proteolytic and cardioprotective function of ABHD5. ABHD5 acts
Indexed as
Lipid Droplets1-Acylglycerol-3-Phosphate O-Acyltransferase3T3-L1 CellsAnimalsHeart FailureHistone DeacetylasesHumansMiceProtein BindingProteolysisRepressor ProteinsSerine Proteases1-Acylglycerol-3-Phosphate O-AcyltransferaseABHD5 protein, humanHDAC4 protein, humanHistone DeacetylasesRepressor ProteinsSerine Proteases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.