Evidence map›Paper›PMID 31741904›Full record

ArticleIndian journal of endocrinology and metabolism

Long-term Response to Recombinant Human Growth Hormone Therapy in Indian Children with Growth Hormone Deficiency.

Monita Gahlot, Alpesh Goyal, Arun K C Singh, Viveka P Jyotsna, Nandita Gupta, Rajesh Khadgawat

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Monita GahlotDepartment of Dietetics, All India Institute of Medical Sciences, New Delhi, India.
Alpesh GoyalDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Arun K C SinghDepartment of Endocrinology and Metabolism, Sarvodaya Hospital and Research Centre, Faridabad, Haryana, India.
Viveka P JyotsnaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Nandita GuptaDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Rajesh KhadgawatDepartment of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
All India Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGrowth hormone deficiency (GHD) remains the most common indication for use of recombinant human growth hormone (rhGH) therapy in clinical practice. However, there is a paucity of studies focusing on long-term response to rhGH therapy in the Indian context.

aimTo determine the response to rhGH therapy and its predictors in children with GHD followed up at a tertiary care center in North India. MATERIALS AND

methodsWe performed a retrospective review of the records of children with GHD who received rhGH therapy for at least 1 year. The relevant anthropometric, biochemical and radiological data at baseline and follow-up were recorded.

resultsA total of 99 children (64 boys, 35 girls; 61 isolated GHD, 38 multiple pituitary hormone deficiency) were studied. The mean (±SD) age and height SDS at treatment initiation were 12.4 (±3.0) years and -4.0 (±1.1) respectively, while median (IQR) serum insulin-like growth factor 1 (IGF-1) and peak growth hormone level on clonidine stimulation were 73 (25-167) ng/ml and 1.1 (0.4-3.6) ng/ml respectively. The height velocity was highest during the first year of treatment (10.6 ± 3.0 cm/year), declining to 8.7 ± 2.7 and 7.9 ± 2.2 cm/year during second and third year, respectively. Over the subsequent years, there was further graded fall in height velocity, declining to 4.8 ± 3.6 cm/year (

conclusionsThis study provides data on long-term response to rhGH therapy and its predictors in Indian children with GHD.

Indexed as

Growth hormone deficiencyheight velocityIndiapredictors of responserecombinant human growth hormone

Identifiers

PMID31741904
PMCPMC6844160
OpenAlexW2978728748

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.