Evidence map›Paper›PMID 31741854›Full record

ArticleInternational journal of ophthalmology2019

Calpastatin participates in the regulation of cell migration in BAP1-deficient uveal melanoma cells.

Han Yue, Feng-Xi Meng, Jiang Qian, Bin-Bin Xu, Gang Li, Ji-Hong Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Han YueDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Feng-Xi MengDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Jiang QianDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Bin-Bin XuDepartment of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Gang LiShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200433, China.
Ji-Hong WuShanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200433, China.
Eye & ENT Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo detect how BRCA-associated protein 1 (BAP1) regulates cell migration in uveal melanoma (UM) cells.

methodsWound healing and transwell assays were performed to detect UM cell migration abilities. Protein chip, immunoprecipitations and surface plasmon resonance analyses were applied to identify BAP1 protein partners. Western blot and calpain activity assays were used to test the expression and function of calpastatin (CAST).

resultsCAST protein was confirmed as a new BAP1 protein partner, and loss of BAP1 reduced the expression and function of CAST in UM cells. The overexpression of CAST rescued the cell migration phenotype caused by BAP1 loss.

conclusionBAP1 interacts with CAST in UM cells, and CAST and its subsequent calpain pathway may mediate BAP1-related cell migration regulation.

Indexed as

BRCA-associated protein 1calpastatincell migrationuveal melanoma

Identifiers

PMID31741854
PMCPMC6848861
OpenAlexW2982192641

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.