Evidence map›Paper›PMID 31741727›Full record

ArticleRare tumors2019

Cancer antigen 125 is associated with disease status in uterine carcinosarcoma.

Malcolm Strachan Ross, Chelsea Kilpatrick Chandler, Koji Matsuo, John Austin Vargo, Esther Elishaev, Nalyn Siripong, Jessica Layne Berger, Joseph Leo Kelley, Sarah Elizabeth Taylor

Open access · goldAbstract read
In one paragraph

Article in Rare tumors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Prognostic Factors for Uterine Sarcoma and Carcinosarcoma: Insights from a 10-Year Follow-Up Study.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Malcolm Strachan RossDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Magee-Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-7696-0663
Chelsea Kilpatrick ChandlerDepartment of Obstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Koji MatsuoDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
John Austin VargoDivision of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Esther ElishaevDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Nalyn SiripongClinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Jessica Layne BergerDepartment of Obstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Joseph Leo KelleyDepartment of Obstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Sarah Elizabeth TaylorDepartment of Obstetrics and Gynecology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
University of Pittsburgh Medical Center · USMagee-Womens Hospital · USUniversity of Pittsburgh · USUniversity of Southern California · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
NCATS NIH HHS UL1 TR001857
6 · The paper itself

Abstract

Uterine carcinosarcoma is a rare and aggressive tumor with poor outcomes. Cancer antigen 125 is routinely used to track the disease course of ovarian cancer and has been suggested as a biomarker in other aggressive forms of uterine cancer. We sought to characterize cancer antigen 125 as a potential biomarker of disease status in uterine carcinosarcoma. Clinical and pathological data were abstracted for patients who had surgical staging for a pathologically confirmed uterine carcinosarcoma at our institution from January 2000 to March 2014. Non-parametric tests were used to compare changes in cancer antigen 125. Elevated cancer antigen 125 (>35 U/mL) as a predictor of survival was assessed via Kaplan-Meier curves. Among the 153 patients identified, 66 patients had at least one paired measure of cancer antigen 125 drawn preoperatively, post-treatment, or at the time of disease recurrence, and 19 patients had cancer antigen-125 levels at all three time points. Analysis of the 51 patients with both preoperative and post-treatment values found a significant drop in cancer antigen 125 (

Indexed as

cancer antigen 125survivalUterine carcinosarcoma

Identifiers

PMID31741727
PMCPMC6843728
OpenAlexW2984913945

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.