Evidence map›Paper›PMID 31741633›Full record

ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2019

Inhibition of γ/β Globin Gene Switching in CD 34

Seyyed Asadallah Taghavi, Kamran Mousavi Hosseini, Gholamhossein Tamaddon, Leila Kasraian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Transcriptional regulators of fetal hemoglobin.Hematology, transfusion and cell therapy · 2024
    Review
  3. Review
  4. Nucleic Acid Therapy for β-Thalassemia.Biologics : targets & therapy · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Seyyed Asadallah Taghavi1High Institute for Research and Education in Transfusion Medicine, Blood Transfusion Research Center, Tehran, Iran.
Kamran Mousavi Hosseini1High Institute for Research and Education in Transfusion Medicine, Blood Transfusion Research Center, Tehran, Iran.ORCID 0000-0003-1092-7726
Gholamhossein Tamaddon2Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Leila Kasraian1High Institute for Research and Education in Transfusion Medicine, Blood Transfusion Research Center, Tehran, Iran.
High Institute for Education and Research in Transfusion Medicine · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The induction of fetal haemoglobin (Hb F), due to the sustained clinical effects, is one of the most promising methods for the treatment of β hemoglobinopathies, such as thalassemia major and sickle cell disease (SCD). Inhibition of γ-globin gene silencing, possibly is a suitable strategy to induce HbF expression in these patients. In this study, the possibility of increasing HbF in the CD34

Indexed as

BCL11AErythroid cellsGene silencingSiRNA

Identifiers

PMID31741633
PMCPMC6825069
OpenAlexW2946177119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.