Evidence map›Paper›PMID 31741615›Full record

ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2019

Evaluation of Cytogenetic Abnormalities in Patients with Acute Lymphoblastic Leukemia.

Pavan Reddy, Ramesh Shankar, Teena Koshy, Venkatraman Radhakrishnan, Prasanth Ganesan, P K Jayachandran, Manikandan Dhanushkodi, Nikita Mehra, S Krupashankar, P Manasa and 5 more

Abstract read
In one paragraph

Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Overview on Aneuploidy in Childhood B-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Pavan Reddy *1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
Ramesh Shankar *2Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute (WIA), Adyar, Chennai, India.
Teena Koshy3Department of Human Genetics, Sri Ramachandra University, Porur, Chennai, 600 116 India.
Venkatraman Radhakrishnan1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
Prasanth Ganesan1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
P K Jayachandran1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
Manikandan Dhanushkodi1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
Nikita Mehra1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
S Krupashankar1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
P Manasa2Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute (WIA), Adyar, Chennai, India.
R P Nagare2Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute (WIA), Adyar, Chennai, India.
R Swaminathan4Division of Epidemiology and Cancer Registry, Cancer Institute (WIA), Adyar, Chennai, India.
Krishnarathinam Kannan1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
T G Sagar1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.
T S Ganesan1Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020 India.ORCID 0000-0002-4671-8099
Cancer Institute (WIA) · INSri Ramachandra Institute of Higher Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukemia (ALL) accounts for 20% of all adult leukemias and is the most common leukemia during childhood (80%). We present data on cytogenetics of ALL from a tertiary centre in India correlating it with clinical factors. Karyotyping of bone marrow samples of 204 patients with newly diagnosed ALL was performed with standard G-banding technique. Clinical data of patients was obtained from case records. Survival was estimated using Kaplan-Meir curves and compared by the log-rank test. Univariate and multivariate analysis was done for survival with age, sex, immunophenotype, hyperleukocytosis, risk type, remission status and cytogenetics. The most common karyotypes observed were normal in 39.7% (N = 81), hyperdiploidy in 12.7% (N = 26), t(9;22) in 4.4% (N = 9), t(1;19) in 3.9% (N = 8). Adults with ALL had worse survival compared with pediatric patients (HR 3.62; 2.03-6.45 95% CI,

Indexed as

Acute lymphoblastic leukemiaCytogeneticsIndiaKaryotypeOverall survival

Identifiers

PMID31741615
PMCPMC6825071
OpenAlexW2938809520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.