ArticleActa clinica Croatica2019
SPINAL ANAESTHESIA-INDUCED HYPOTENSION IN OBSTETRICS: PREVENTION AND THERAPY.
Article in Acta clinica Croatica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Preoperative Shock Index and Hypotension After Spinal Anaesthesia for Non-elective Caesarean Section: A Prospective Observational Study
Prospective, Observational and Bicentric Study of the Management of Arterial Hypotension During Planned Caesarean Section. Practice Comparison Between a Referral Center Using According to Service Protocol, an Intravenous Ephedrine/Phenylephrine Mixture at the PSE Versus Another Referral Center Using According to Service Protocol Intravenous Baby Noradrenaline
The Efficacy of Adding Leg Wrapping to Prophylactic Norepinephrine Infusion in Reducing the Incidence of Post-spinal Hypotension in Elective Cesarean Section: A PROSPECTIVE DOUBLE- BLINDED RANDOMIZED CLINICAL TRIAL
Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Comparing the efficacy and safety of unilateral versus bilateral spinal anesthesia: a meta-analysis and systematic review.Annals of medicine · 2026Pooled it
- Effect of anesthesia on the success rate of external cephalic version: GRADE- assessed systematic review and meta-analysis of randomized controlled trials.Systematic reviews · 2024Pooled it
- Comparative efficacy and safety of prophylactic norepinephrine and phenylephrine in spinal anesthesia for cesarean section: A systematic review and meta-analysis with trial sequential analysis.Frontiers in pharmacology · 2022Pooled it
- Efficacy of fentanyl combined with bupivacaine and morphine for spinal anesthesia during cesarean section: A double-blind randomized controlled trial.The Journal of international medical research · 2025Trial
- Effects of Prophylactic Infusion of Equivalent Doses of Norepinephrine and Phenylephrine in Preventing Spinal Anesthesia-Induced Hypotension During Cesarean Delivery on Fetal and Maternal Outcomes: A Dual-Center, Non-Inferiority Controlled Trial.Drug design, development and therapy · 2025Trial
- Norepinephrine or Phenylephrine to Prevent Spinal Anesthesia-Induced Hypotension During Cesarean Section: A Double-Blinded, Randomized, Controlled Study of Fetal Cerebral Perfusion.Drug design, development and therapy · 2025Trial
- Effect of intravenous palonosetron on hypotension induced by spinal anesthesia for cesarean section: A randomized controlled trial.PloS one · 2024Trial
- Prevalence and factors associated with hypotension after spinal anesthesia during cesarean section at public hospitals in Harar town, Eastern Ethiopia.Journal of public health research · 2026Article
- Comparison of crystalloid preloading and co-loading for the prevention of spinal induced-hypotension in elective cesarean delivery: a prospective cohort study.Annals of medicine and surgery (2012) · 2026Article
- Neonatal outcome following norepinephrine versus phenylephrine for treatment of spinal-induced hypotension among women undergoing caesarean section: systematic review and meta-analysis of randomised controlled trials.Perioperative medicine (London, England) · 2026Review
- Article
- Prediction of spinal anesthesia-induced hypotension during cesarean delivery: a narrative review.Journal of anesthesia, analgesia and critical care · 2026Review
- A Nomogram for Predicting the Risk of Spinal Anesthesia-Induced Hypotension in Older Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Prevention of post-spinal hypotension in high risk cesarean delivery: A systematic review and updated network meta-analysis of prophylactic vasopressor infusions.Indian journal of anaesthesia · 2026Article
- Position-Induced Change in Carotid Corrected Flow Time Predicts Spinal Hypotension in Cesarean Delivery.International journal of women's health · 2026Article
- Effectiveness of lumbar wedge in preventing intraoperative hypotension during cesarean delivery in multiple gestation: a retrospective analysis.BMC pregnancy and childbirth · 2025Observational
- Managing spinal anesthesia-induced hypotension in cesarean section: emerging techniques and evidence-based strategies - a narrative review.Annals of medicine and surgery (2012) · 2025Review
- Dissecting Vasopressor Efficacy in the Management of Maternal Hypotension in Preeclamptic Cesarean Delivery: A Systematic Review of Randomized Controlled Trials.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regional centro-axial anaesthesia, primarily spinal block, is the preferred method of anaesthesia for elective caesarean section because it entails fewer risks for the mother and the foetus compared to general anaesthesia. The most common side effect associated with spinal block is hypotension due to sympatholysis, occurring in up to 75% of cases. Spinal block-induced sympatholysis leads to vasodilatation and consequently causes maternal hypotension, which may compromise uterine blood flow and foetal circulation, and thus cause foetal hypoxia, bradycardia and acidosis. The selection of the most efficient treatment strategy to achieve haemodynamic stability during spinal anaesthesia for caesarean section continues to be one of the main challenges in obstetric anaesthesiology. A number of measures for the prevention and treatment of spinal block-induced hypotension are used in clinical practice, such as preloading and coloading with crystalloid and/or colloid infusion, wrapping of lower limbs with compression stockings or bandages, administering an optimal dose of local anaesthetic and achieving an optimal spinal block level, left tilt positioning, and administering inotropes and vasopressors. Instead of administering vasopressors after a drop in blood pressure has already occurred, the latest algorithms recommend a prophylactic administration of vasopressor infusion. The preferred vasoconstrictor in this case is phenylephrine, which is associated with a lower incidence of foetal acidosis, and maternal nausea and vomiting compared to other vasoconstrictors.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.