Observational studyJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Interaction between the effects of proton pump inhibitors and aspirin on gastric wall sestamibi uptake on myocardial perfusion imaging.
Observational study in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Drug interactions involving therapeutic radiopharmaceuticals: a systematic review.EJNMMI radiopharmacy and chemistry · 2026Review
- Combined effect of ozone and household air pollution on COPD in people aged less than 50 years old.Thorax · 2023Article
- Joint effects of meteorological factors and PMEnvironmental health and preventive medicine · 2023Article
- Phantoms to simulate gastrointestinal artefact in MPI.Physical and engineering sciences in medicine · 2022Article
- Reducing the effect of proton pump inhibitors augmenting gastrointestinal sestamibi uptake.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- The way to the heart is through the stomach; PPI's, aspirin, and gastric radiotracer activity.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Duration of proton pump inhibitor abstinence before myocardial perfusion scintigraphy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased gastric wall activity on myocardial perfusion imaging (MPI) is associated with proton pump inhibitor (PPI) therapy; however, the mechanism is unknown. We proposed a role for gastric mucosal prostaglandin synthesis and asked whether concurrent use of aspirin would antagonize this effect.
methodsAn observational study was performed of 319 patients undergoing technetium-99m sestamibi (MIBI) rest/stress MPI. We assessed the effects of taking PPIs, aspirin and their interaction on the principle outcome of clinically significant gastric wall activity.
resultsThe outcome was observed in 13% of patients taking neither a PPI nor aspirin, 22% of those taking aspirin only, 51% taking a PPI only and 33% of those taking both. Adjusted odd ratios (95% confidence intervals) were 6.3 (CI 2.8-14.0; p < .001) for taking a PPI only, 1.8 (CI 0.8-3.9; p = .16) for taking aspirin only, and 3.0 (CI 1.4-6.5; p = .005) for taking the combination of a PPI and aspirin. There was evidence of negative statistical interaction between the two drug effects using additive (p = .006) and multiplicative (p = .016) scales.
conclusionsPPI use was strongly associated with enhanced gastric wall activity on MPI; however, concurrent aspirin appears to reduce the effect. Enhanced local prostaglandin synthesis may mediate the PPI effect.
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