ReviewReviews in endocrine & metabolic disorders2019
Oral microbiota-induced periodontitis: a new risk factor of metabolic diseases.
Review in Reviews in endocrine & metabolic disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Risk of cancer in periodontal disease: an umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
- Diversity and taxonomic differences in the oral microbiota of stroke patients: a systematic review and meta-analysis.Frontiers in microbiology · 2026Pooled it
- Periodontal disease and cardiovascular disease: umbrella review.BMC oral health · 2024Pooled it
- Laryngopharyngeal reflux, gastroesophageal reflux and dental disorders: A systematic review.PloS one · 2020Pooled it
- Periodontal disease-associated oral and gut microbiome changes in female rheumatoid arthritis patients.BMC oral health · 2026Article
- The Biological Role of the Signal Transducer and Activator of Transcription 1 (STAT1)-miR-221/222-3p-p21 Activated Kinase 1 (PAK1) Axis in Experimental Periodontitis.Inflammation · 2025Article
- Evaluation of the Oral Microbiome in Patients with Alström and Bardet-Biedl Syndromes and Their Heterozygous Family Members.Microorganisms · 2025Article
- Exploring the Gut and Oral Microbiomes in Psychoactive Substance Use: A Scoping Review of Clinical Studies.Journal of neurochemistry · 2025Article
- Oral health implications in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- A Potential Link Between Oral Microbiota and Female Reproductive Health.Microorganisms · 2025Review
- Experimental Murine Periodontitis Increases Salivary Gland IgA-Producing B Cells Following Oral Dysbiosis.Microbiology and immunology · 2025Article
- Probiotics and amelioration of periodontitis: significant roles ofFrontiers in microbiology · 2025Article
- Hallmarks of Periodontitis.Current medicinal chemistry · 2025Review
- Altered oral microbiome composition in mental disorders: a systematic review and meta-analysis.Journal of oral microbiology · 2025Review
- The profile of oral microbiome in Chinese elderly population associated with aging and systemic health status.BMC oral health · 2024Article
- Bibliometric analysis of the association between periodontal disease and cardiovascular disease.Heliyon · 2024Article
- Gut Microbiome and Its Role in Valvular Heart Disease: Not a "Gutted" Relationship.Life (Basel, Switzerland) · 2024Review
- High casein concentration induces diarrhea through mTOR signal pathway inhibition in post-weaning piglets.Frontiers in microbiology · 2024Article
- Periodontitis Continuum: Antecedents, Triggers, Mediators, and Treatment Strategies.Current medicinal chemistry · 2024Review
- The Role of Dysbiotic Oral Microbiota in Cardiometabolic Diseases: A Narrative Review.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has recently become evident that the periodontium (gingiva, desmodontal ligament, cementum and alveolar bone) and the associated microbiota play a pivotal role in regulating human health and diseases. The oral cavity is the second largest microbiota in the body with around 500 different bacterial species identified today. When disruption of oral cavity and dysbiosis occur, the proportion of strict anaerobic Gram-negative bacteria is then increased. Patients with periodontitis present 27 to 53% more risk to develop diabetes than the control population suggesting that periodontitis is an aggravating factor in the incidence of diabetes. Moreover, dysbiosis of oral microbiota is involved in both periodontal and metabolic disorders (cardiovascular diseases, dyslipidaemia …). The oral diabetic dysbiosis is characterized by a specific bacteria Porphyromonas, which is highly expressed in periodontal diseases and could exacerbate insulin resistance. In this review, we will address the nature of the oral microbiota and how it affects systemic pathologies with a bidirectional interaction. We also propose that using prebiotics like Akkermansia muciniphila may influence oral microbiota as novel therapeutic strategies. The discovery of the implication of oral microbiota for the control of metabolic diseases could be a new way for personalized medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.