ArticleAnnals of biomedical engineering2020
Ventricular Flow Field Visualization During Mechanical Circulatory Support in the Assisted Isolated Beating Heart.
Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Left ventricular flow dynamics by cardiac imaging techniques in heart failure patients: state of the art.Cardiovascular ultrasound · 2025Review
- Optimization of flow rate and orientation of outflow graft at implantation for patients with left ventricular assist device.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Influence of LVAD Cannula Outflow Graft Flow Rate and Location on Fluid-Particle Interactions and Thrombi Distribution: A Primary Numerical Study.Journal of cardiovascular translational research · 2024Article
- A Computational Investigation of the Effects of Temporal Synchronization of Left Ventricular Assist Device Speed Modulation with the Cardiac Cycle on Intraventricular Hemodynamics.Annals of biomedical engineering · 2024Article
- Benchtop Models of Patient-Specific Intraventricular Flow During Heart Failure and LVAD Support.Journal of biomechanical engineering · 2023Article
- Impact of dobutamine stress on diastolic energetic efficiency of healthy left ventricle: anFrontiers in cardiovascular medicine · 2023Article
- The role of innovative modeling and imaging techniques in improving outcomes in patients with LVAD.Frontiers in cardiovascular medicine · 2023Review
- Effect of left ventricular assist device on the hemodynamics of a patient-specific left heart.Medical & biological engineering & computing · 2022Article
- Inflow cannula position as risk factor for stroke in patients with HeartMate 3 left ventricular assist devices.Artificial organs · 2022Article
- Effects of the atrium on intraventricular flow patterns during mechanical circulatory support.The International journal of artificial organs · 2022Article
- Pump position and thrombosis in ventricular assist devices: Correlation of radiographs and CT data.The International journal of artificial organs · 2021Article
- Validation of numerically simulated ventricular flow patterns during left ventricular assist device support.The International journal of artificial organs · 2021Article
- The influence of left ventricular assist device inflow cannula position on thrombosis risk.Artificial organs · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Investigations of ventricular flow patterns during mechanical circulatory support are limited to in vitro flow models or in silico simulations, which cannot fully replicate the complex anatomy and contraction of the heart. Therefore, the feasibility of using echocardiographic particle image velocimetry (Echo-PIV) was evaluated in an isolated working heart setup. Porcine hearts were connected to an isolated, working heart setup and a left ventricular assist device (LVAD) was implanted. During different levels of LVAD support (unsupported, partial support, full support), microbubbles were injected and echocardiographic images were acquired. Iterative PIV algorithms were applied to calculate flow fields. The isolated heart setup allowed different hemodynamic situations. In the unsupported heart, diastolic intra-ventricular blood flow was redirected at the heart's apex towards the left ventricular outflow tract (LVOT). With increasing pump speed, large vortex formation was suppressed, and blood flow from the mitral valve directly entered the pump cannula. The maximum velocities in the LVOT were significantly reduced with increasing support. For the first time, cardiac blood flow patterns during LVAD support were visualized and quantified in an ex vivo model using Echo-PIV. The results reveal potential regions of stagnation in the LVOT and, in future the methods might be also used in clinical routine to evaluate intraventricular flow fields during LVAD support.
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