ArticleEuropean journal of epidemiology2020
Serum albumin and atrial fibrillation: insights from epidemiological and mendelian randomization studies.
Article in European journal of epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations.Genome medicine · 2022Pooled it
- Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack.Stroke and vascular neurology · 2021Pooled it
- Relationship Between Serum Albumin and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- Association of the red blood cell distribution width-to-albumin ratio with incident depression and depressive symptom trajectories in older adults.European archives of psychiatry and clinical neuroscience · 2026Article
- Effects of resistance, endurance, and combined exercise training on body composition, glycemic control, and serum albumin in women with type 2 diabetes: A randomized controlled study.Metabolism open · 2026Article
- The association between albumin/neutrophil-to-lymphocyte ratio score and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database.Journal of thoracic disease · 2026Article
- Association Between Red Blood Cell Distribution Width-to-Albumin Ratio and Stroke Among Adults in the United States.Anatolian journal of cardiology · 2026Article
- Association between blood urea nitrogen-to-albumin ratio and mortality among atrial fibrillation patients admitted to the intensive care unit.BMC cardiovascular disorders · 2026Article
- The association between blood urea nitrogen to serum albumin ratio and all-cause mortality in critically ill patients with atrial fibrillation.European journal of medical research · 2026Article
- Red Blood Cell Distribution Width-to-Albumin Ratio (RAR) Is an Independent Predictor of Mortality in Non-Anemic Elderly with Hip Fractures.International journal of general medicine · 2026Article
- Association of the advanced lung cancer inflammation index and controlling nutritional status score with atrial fibrillation in COPD patients: a multicenter cross-sectional study.Frontiers in nutrition · 2026Article
- Reference Range of Red Cell Distribution Width-to-Albumin Ratio in Healthy US Adults: A Cross-Sectional Study.BioMed research international · 2026Article
- Prognostic worth of admission blood glucose to albumin ratio: evaluation in patients following percutaneous coronary intervention with and without type 2 diabetes mellitus.BMC cardiovascular disorders · 2025Article
- Association between RAR and the prevalence and prognosis of suicidal ideation: evidence from a large population-based study.BMC psychiatry · 2025Article
- Association between red cell distribution width/serum albumin ratio and Parkinson's disease.European journal of medical research · 2025Article
- Association between blood test indicators and atrial fibrillation in elderly patients aged 65 and above in the Central Jiangsu region: a cross-sectional study.BMC cardiovascular disorders · 2025Article
- Association Between the Naples Score and Recurrence in Patients With Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation.Cardiovascular therapeutics · 2025Article
- Article
- Associations Between Albumin/Neutrophil-to-Lymphocyte Ratio Score and New-Onset Atrial Fibrillation in Patients with Acute Myocardial Infarction Undergoing PCI.Journal of inflammation research · 2025Article
- Red cell distribution width/albumin ratio as a marker for metabolic syndrome: findings from a cross-sectional study.BMC endocrine disorders · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Low serum albumin level is linked to the emergence of many cardiovascular diseases, including AF. In this study, we aim to characterize the nature and magnitude of the prospective association between serum albumin and incident AF in the Atherosclerosis Risk in Communities (ARIC) Study and investigate any causal relevance to the association between them. ARIC Study is a population-based, prospective, cohort study of cardiovascular risk factors in four US communities, initially consisting of 15,792 participants, aged 45-64 years, recruited between 1987 and 1989 (visit 1). The final sample size was 12,833 in this study. Baseline (visit 1) characteristics were compared between groups using one-way ANOVA test, Chi square test, or Kruskal-Wallis test as appropriate. We used multivariable Cox' hazard regression models to assess the association between albumin and incident AF. Two-sample Mendelian randomization (MR) based on publicly available summary-level data from genome-wide association studies was used to estimate the causal influence of the serum albumin and incident AF. During a median follow-up of 25.1 years, 2259 (17.6%) participants developed incident AF. After multiple adjustment, serum albumin was inversely associated with incidence of AF [HR = 0.90, 95% CI 0.86-0.94, per SD (0.27 g/dL) increase; HR = 0.80, 95% CI 0.71-0.91, Q4 vs. Q1]. In MR analysis, we detected no evidence for a causal relation between serum albumin level and AF in inverse-variance weighted (IVW) method (odds ratio: 0.996, 95% CI 0.980-1.012, per 1 g/dL increase of albumin; P = 0.620) without evidence of heterogeneity between estimates from individual SNPs (P
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