Evidence map›Paper›PMID 31741103›Full record

ArticleOdontology2020

Genetic polymorphisms influence gene expression of human periodontal ligament fibroblasts in the early phases of orthodontic tooth movement.

Erika Calvano Küchler, Agnes Schröder, Paola Corso, Rafaela Scariot, Gerrit Spanier, Peter Proff, Christian Kirschneck

Abstract read
PubMed Publisher
In one paragraph

Article in Odontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Single Nucleotide Polymorphisms inInternational journal of environmental research and public health · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Erika Calvano KüchlerDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Av do Café, S/N, Ribeirão Preto, 14027-250, SP, Brazil.
Agnes SchröderDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Paola CorsoDepartment of Oral and Maxillofacial Surgery, Universidade Positivo, Prof. Pedro Viriato Parigot de Souza Street, Cidade Industrial, Curitiba, 81280-330, Parana, Brazil.
Rafaela ScariotDepartment of Oral and Maxillofacial Surgery, Universidade Positivo, Prof. Pedro Viriato Parigot de Souza Street, Cidade Industrial, Curitiba, 81280-330, Parana, Brazil.
Gerrit SpanierDepartment of Cranial and Maxillofacial Surgery, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Peter ProffDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Christian KirschneckDepartment of Orthodontics, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. christian.kirschneck@ukr.de.ORCID http://orcid.org/0000-0001-9473-8724
University of Regensburg · DEUniversidade Positivo · BRUniversidade de São Paulo · BR

Funding

Bavarian University Centre for Latin America BAYLAT Kirschneck 12/2017Fundação Amazônia Paraense de Amparo à Pesquisa Küchler 2015/06866-5
6 · The paper itself

Abstract

Genetic polymorphisms could be involved in the individual rate of OTM (orthodontic tooth movement) corresponding to the clinical phenomenon of "slow movers" and "fast movers". This study evaluated, if genetic polymorphisms in RANK, RANKL, OPG, COX2 and IL6 are associated with the expression of RANKL, OPG, COX2 and IL6 by human periodontal ligament (hPDL) fibroblasts during OTM. Primary hPDL fibroblasts from periodontal connective tissue of teeth extracted from 57 human subjects for medical reasons were collected, isolated, cultivated and characterized. To simulate orthodontic forces in PDL pressure areas, a physiological compressive force of 2 g/cm

Indexed as

Periodontal LigamentTooth Movement TechniquesCells, CulturedFibroblastsHumansOsteoprotegerinPolymorphism, GeneticRANK LigandOsteoprotegerinRANK LigandBoneConnective tissueGenetic polymorphismOrthodonticsPeriodontal ligament

Identifiers

PMID31741103
OpenAlexW2984199202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.