Evidence map›Paper›PMID 31741027›Full record

ArticleWorld journal of urology2020

Urinary biomarkers profiles in patients with neurogenic detrusor overactivity according to their neurological condition.

Claire Richard, Claude Bendavid, Juliette Hascoet, Quentin Alimi, Zine-Eddine Khene, Jacques Kerdraon, Caroline Voiry, Charlène Brochard, Guillaume Bouguen, Laurent Siproudhis and 3 more

Abstract read
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In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Claire RichardDepartment of Urology, Hopital Pontchaillou, University of Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France. clairerichard3@orange.fr.ORCID http://orcid.org/0000-0002-4374-5665
Claude BendavidDepartment of Biochemistry, University of Rennes, Rennes, France.
Juliette HascoetDepartment of Urology, Hopital Pontchaillou, University of Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France.
Quentin AlimiDepartment of Urology, Hopital Pontchaillou, University of Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France.
Zine-Eddine KheneDepartment of Urology, Hopital Pontchaillou, University of Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France.
Jacques KerdraonDepartment of Physical Medicine and Readaptation, Kerpape Institute, Ploemeur, France.
Caroline VoiryDepartment of Physical Medicine and Readaptation, University of Rennes, Rennes, France.
Charlène BrochardDepartment of Gastro-enterology, University of Rennes, Rennes, France.
Guillaume BouguenDepartment of Gastro-enterology, University of Rennes, Rennes, France.
Laurent SiproudhisDepartment of Gastro-enterology, University of Rennes, Rennes, France.
Andrea ManuntaDepartment of Urology, Hopital Pontchaillou, University of Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France.
Xavier GaméDepartment of Urology, University of Toulouse, Toulouse, France.
Benoit PeyronnetDepartment of Urology, Hopital Pontchaillou, University of Rennes, 2 rue Henri Le Guilloux, 35000, Rennes, France.
Université Rennes 2 · FRUniversité de Rennes · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this study was to investigate the disease-specific urinary levels variations of neurotrophins (NGF, BDNF), mediators of inflammation (TGFβ-1, PGE-2) and markers of extracellular matrix alterations (TIMP-2) in patients with multiple sclerosis (MS) spinal cord injury (SCI), or spina bifida (SB), and neurogenic detrusor overactivity (NDO).

methodsA prospective single-center study was conducted between March 2015 and March 2017. Patients aged over 18 years old, with neurological disease, with a urodynamic diagnosis of NDO were included. The urinary levels of NGF, BDNF, TIMP-2, PGE 2, and TGF-β1 were measured using dedicated ELISA kits.

resultsForty-one patients were included: 6 with MS, 20 with SCI, and 15 with spina bifida. The average urinary level of NGF/Cr was significantly higher in MS patients compared to other neurologic populations (8 vs. 0.56 vs. 1.25 pg/mg of creatinine; p = 0.001) as well for the average urinary level of BDNF (88.3 vs. 5 vs. 4.8 pg/mg of creatinine; p < 0.0001). SCI patients had a significantly lower level of TGFβ-1 than SB patients (p = 0.04). The urinary level of PGE2 was significantly correlated with the Body Mass Index (r = 0.61; p = 0.0002).

conclusionAll NDO may not be created equal from the molecular standpoint. Multiple sclerosis patients had higher urinary levels of neurotrophins than in other neurologic populations with NDO. Urinary TGFβ-1, a strong determinant of extracellular matrix, was significantly higher in spina bifida patients compared to SCI patients. These findings underscore the importance of using and interpreting those possible urinary markers in a disease-specific fashion.

Indexed as

AdultAgedBiomarkersFemaleHumansMaleMiddle AgedMultiple SclerosisProspective StudiesSpinal Cord InjuriesSpinal DysraphismUrinary Bladder, NeurogenicUrinary Bladder, OveractiveBiomarkersNeurogenicNeurotrophinsPathophysiologyProteomicsUrinary bladder

Identifiers

PMID31741027
OpenAlexW2983955611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.