Trial reportThe international journal of neuropsychopharmacology2020
Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression.
Trial report in The international journal of neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Electroconvulsive therapy modulates neurite density and free water in discrete white matter compartments in major depression.Research square · 2026Article
- Electroconvulsive Therapy (ECT) and Repetitive Transcranial Magnetic Stimulation (rTMS), Benefits and Adverse Effects in Patients with Depression: A Scoping Review.Journal of clinical medicine · 2026Review
- Clinical and biological markers of electroconvulsive therapy effectiveness: a narrative review.Translational psychiatry · 2026Review
- Physiotherapy for patients with depression: Recent research progress.World journal of psychiatry · 2024Review
- Mechanism of Action of ECT in Depression.Current topics in behavioral neurosciences · 2024Review
- Blood-brain barrier permeability and electroconvulsive therapy: a systematic review.Acta neuropsychiatrica · 2023Review
- Clinical Improvement in Depression and Cognitive Deficit Following Electroconvulsive Therapy.Diagnostics (Basel, Switzerland) · 2023Review
- Neuroimaging study of electroconvulsive therapy for depression.Frontiers in psychiatry · 2023Review
- White matter changes following electroconvulsive therapy for depression: a multicenter ComBat harmonization approach.Translational psychiatry · 2022Article
- Learning induces coordinated neuronal plasticity of metabolic demands and functional brain networks.Communications biology · 2022Article
- The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go?Biological psychiatry · 2022Review
- Current progress in neuroimaging research for the treatment of major depression with electroconvulsive therapy.World journal of psychiatry · 2022Review
- Changes in the geometry and robustness of diffusion tensor imaging networks: Secondary analysis from a randomized controlled trial of young autistic children receiving an umbilical cord blood infusion.Frontiers in psychiatry · 2022Article
- Biophysical mechanisms of electroconvulsive therapy-induced volume expansion in the medial temporal lobe: A longitudinal in vivo human imaging study.Brain stimulationArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundTreatment-resistant depression is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with magnetic resonance imaging with poor antidepressant response. Therefore, the extent to which electroconvulsive therapy, the most effective therapeutic option for treatment-resistant depression, affects white matter microstructure warrants investigation.
methodsA total 13 patients suffering from severe unipolar treatment-resistant depression underwent magnetic resonance imaging with a diffusion tensor imaging sequence before and after undergoing a series of right unilateral electroconvulsive therapy. Diffusivity metrics were compared voxel-wise using tract-based spatial statistics and repeated-measures ANOVA.
resultsA total 12 patients responded to electroconvulsive therapy and 9 were classified as remitters. An increase in axial diffusivity was observed in the posterior limb of the internal capsule of the right hemisphere (PFWE ≤ .05). The increase in this area was higher in the right compared with the left hemisphere (P < .05). No correlation of this effect with treatment response could be found.
conclusionsThe strong lateralization of effects to the hemisphere of electrical stimulation suggests an effect of electroconvulsive therapy on diffusivity metrics which is dependent of electrode placement. Investigation in controlled studies is necessary to reveal to what extent the effects of electroconvulsive therapy on white matter microstructure are related to clinical outcomes and electrode placement.
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