ArticleThe Journal of antimicrobial chemotherapy2020
Heterogeneity of penicillin-non-susceptible group B streptococci isolated from a single patient in Germany.
Article in The Journal of antimicrobial chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Maternal colonization with group B Streptococcus and antibiotic resistance in China: systematic review and meta-analyses.Annals of clinical microbiology and antimicrobials · 2023Pooled it
- Emergence of Group B streptococcus with reduced susceptibility to penicillin in mainland China.New microbes and new infections · 2026Article
- First case of penicillin-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
- Group B Streptococcus colonization, antibiotic resistance, and maternal-neonatal outcomes in late pregnancy: a retrospective study from 2017 to 2024.BMC pregnancy and childbirth · 2026Article
- Penicillin-Binding Proteins inAntibiotics (Basel, Switzerland) · 2026Review
- Increase in Penicillin Non-Susceptibility in Group B Streptococci Alongside Rising Isolation Rates-Based on 24 Years of Clinical Data from a Single University Hospital.Antibiotics (Basel, Switzerland) · 2025Article
- Evidence of a novel sublineage ofMicrobial genomics · 2025Article
- Characterization of Penicillin-Non-Susceptible, Multidrug-Resistant Streptococcus agalactiae Using Whole-Genome Sequencing.Current microbiology · 2025Article
- Molecular Epidemiology of Invasive Group B Streptococcus in South Africa, 2019-2020.The Journal of infectious diseases · 2025Article
- A case of penicillin-resistant group B Streptococcus isolated from a patient in the UK.The Journal of antimicrobial chemotherapy · 2025Article
- Article
- Determination of pilus-islands profile and antibiotic susceptibility ofIranian journal of microbiology · 2023Article
- Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar.BMC infectious diseases · 2022Article
- Genetic diversity and antimicrobial resistance of invasive, noninvasive and colonizing group BAccess microbiology · 2022Article
- Genomic Traits Associated with Virulence and Antimicrobial Resistance of Invasive Group B Streptococcus Isolates with Reduced Penicillin Susceptibility from Elderly Adults.Microbiology spectrum · 2022Article
- Multiple-locus variable-number tandem repeat analysis for genotyping of erythromycin-resistant group B streptococci in Iran.New microbes and new infections · 2022Article
- Clinical and bacterial features of Group B streptococci with reduced penicillin susceptibility from respiratory specimens: a case-control study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- Chewie Nomenclature Server (chewie-NS): a deployable nomenclature server for easy sharing of core and whole genome MLST schemas.Nucleic acids research · 2021Article
- Emergence of Multi-Drug Resistance and Its Association With Uncommon Serotypes ofFrontiers in microbiology · 2021Article
- Multidrug-ResistantMicroorganisms · 2020Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesStreptococcus agalactiae [group B streptococci (GBS)] have been considered uniformly susceptible to penicillin. However, increasing reports from Asia and North America are documenting penicillin-non-susceptible GBS (PRGBS) with mutations in pbp genes. Here we report, to the best of our knowledge, the first two PRGBS isolates recovered in Europe (AC-13238-1 and AC-13238-2), isolated from the same patient.
methodsTwo different colony morphologies of GBS were noted from a surgical abscess drainage sample. Both were serotyped and antimicrobial susceptibility testing was performed by different methodologies. High-throughput sequencing was done to compare the isolates at the genomic level, to identify their capsular type and ST, to evaluate mutations in the pbp genes and to compare the isolates with the genomes of other PRGBS isolates sharing the same serotype and ST.
resultsIsolates AC-13238-1 and AC-13238-2 presented MICs above the EUCAST and CLSI breakpoints for penicillin susceptibility. Both shared the capsular type Ia operon and ST23. Genomic analysis uncovered differences between the two isolates in seven genes, including altered pbp genes. Deduced amino acid sequences revealed critical substitutions in PBP2X in both isolates. Comparison with serotype Ia clonal complex 23 PRGBS from the USA reinforced the similarity between AC-13238-1 and AC-13238-2, and their divergence from the US strains.
conclusionsOur results support the in-host evolution of β-lactam-resistant GBS, with two PRGBS variants being isolated from one patient.
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