ArticleNature ecology & evolution2019
Fluorescent biomarkers demonstrate prospects for spreadable vaccines to control disease transmission in wild bats.
Article in Nature ecology & evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Dynamics of influenza transmission in vampire bats revealed by longitudinal monitoring and a large-scale anthropogenic perturbation.Science advances · 2025Article
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- Rabies transmitted from vampires to cattle: An overview.PloS one · 2025Article
- Advances in understanding bat infection dynamics across biological scales.Proceedings. Biological sciences · 2024Review
- Multidisciplinary Collaboration Mitigating Health Crises Rooted in Wildlife-Human Interaction.Public health reviews · 2024Article
- Optimizing the delivery of self-disseminating vaccines in fluctuating wildlife populations.PLoS neglected tropical diseases · 2023Article
- Inferring the disruption of rabies circulation in vampire bat populations using a betaherpesvirus-vectored transmissible vaccine.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Effects of culling vampire bats on the spatial spread and spillover of rabies virus.Science advances · 2023Article
- The Amazonian Tropical Bites Research Initiative, a hope for resolving zoonotic neglected tropical diseases in the One Health era.International health · 2023Article
- Quantifying Spillover Risk with an Integrated Bat-Rabies Dynamic Modeling Framework.Transboundary and emerging diseases · 2023Article
- Rabies in a postpandemic world: resilient reservoirs, redoubtable riposte, recurrent roadblocks, and resolute recidivism.Animal diseases · 2023Review
- Ecological determinants of rabies virus dynamics in vampire bats and spillover to livestock.Proceedings. Biological sciences · 2022Article
- A review of mechanistic models of viral dynamics in bat reservoirs for zoonotic disease.Pathogens and global health · 2020Review
- Epidemiology and biology of a herpesvirus in rabies endemic vampire bat populations.Nature communications · 2020Article
- Self-disseminating vaccines to suppress zoonoses.Nature ecology & evolution · 2020Review
- Personality affects dynamics of an experimental pathogen in little brown bats.Royal Society open science · 2020Article
- Update on lyssaviruses and rabies: will past progress play as prologue in the near term towards future elimination?Faculty reviews · 2020Review
- A batty concept goes viral.Nature ecology & evolution · 2019Article
- Recombinant transmissible vaccines will be intrinsically contained despite the ability to superinfect.Expert review of vaccinesArticle
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
Abstract
Vaccines that autonomously transfer among individuals have been proposed as a strategy to control infectious diseases within inaccessible wildlife populations. However, rates of vaccine spread and epidemiological efficacy in real-world systems remain elusive. Here, we investigate whether topical vaccines that transfer among individuals through social contacts can control vampire bat rabies-a medically and economically important zoonosis in Latin America. Field experiments in three Peruvian bat colonies, which used fluorescent biomarkers as a proxy for the bat-to-bat transfer and ingestion of an oral vaccine, revealed that vaccine transfer would increase population-level immunity up to 2.6 times beyond the same effort using conventional, non-spreadable vaccines. Mathematical models showed that observed levels of vaccine transfer would reduce the probability, size and duration of rabies outbreaks, even at low but realistically achievable levels of vaccine application. Models further predicted that existing vaccines provide substantial advantages over culling bats-the policy currently implemented in North, Central and South America. Linking field studies with biomarkers to mathematical models can inform how spreadable vaccines may combat pathogens of health and conservation concern before costly investments in vaccine design and testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.