ArticleNature genetics2019
Comparative genetic architectures of schizophrenia in East Asian and European populations.
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Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 407 papers, 19 of them syntheses that pooled it.
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407citing papers in PubMed, 19 pooled it
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Who cites it
407 citing papers in PubMed, 19 syntheses or guidelines pooled it.
- Integrating cell-type-specific gene expression and genome-wide associations identifies risk genes for schizophrenia.Molecular psychiatry · 2026Pooled it
- Contribution of copy number variants to schizophrenia in East Asian populations.Nature genetics · 2026Pooled it
- Multiancestry and Multitrait GWAS Meta-Analysis on Schizophrenia With a Sample of 322,321 Unveils Genetic Links to Chronic Lung Diseases.Genes, brain, and behavior · 2026Pooled it
- Multi-Trait Genetic Insights Into Schizophrenia Across Ancestries: Genome-Wide Association Meta-Analyses, Machine Learning, and Drug Repurposing Study.Brain and behavior · 2026Pooled it
- Cross-ancestry genome-wide association studies of liver function biomarkers uncover pleiotropic variants, systemic disease links and therapeutic targets.Genome medicine · 2026Pooled it
- Identification of 1q25.2 as a novel shared locus between schizophrenia and major depressive disorder in east Asians by integrative analyses.Translational psychiatry · 2025Pooled it
- Multi-ancestry genome-wide association analyses of polycystic ovary syndrome.Nature genetics · 2025Pooled it
- Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.Nature genetics · 2025Pooled it
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- Characterizing pleiotropy among bipolar disorder, schizophrenia, and major depression: a genome-wide cross-disorder meta-analysis.Psychological medicine · 2025Pooled it
- Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia.Nature human behaviour · 2025Pooled it
- Genome-wide meta-analysis identifies ancestry-specific loci for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- The impact of assortative mating, participation bias and socioeconomic status on the polygenic risk of behavioural and psychiatric traits.Nature human behaviour · 2024Pooled it
- Large-scale cross-ancestry genome-wide meta-analysis of serum urate.Nature communications · 2024Pooled it
- Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer.Schizophrenia bulletin · 2024Pooled it
- Shared genetic architectures of educational attainment in East Asian and European populations.Nature human behaviour · 2024Pooled it
- Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders.Nature human behaviour · 2024Pooled it
- Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.Nature communications · 2023Pooled it
- Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease.Molecular psychiatry · 2023Pooled it
- Identification of hub genes involved in early-onset schizophrenia: from genetic susceptibility to predicted regulated gene expression.Molecular psychiatry · 2026Article
347 more citing papers are in PubMed but not listed here.
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Authors and funding
59 authors.
Max Lam *Bio-X Institutes, Shanghai Jiao Tong University and Research Division, Institute of Mental Health Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-4256-7844
Chia-Yen Chen *Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Zhiqiang LiBiomedical Sciences Institute of Qingdao University, Qingdao Branch of Shanghai Jiao Tong University Bio-X Institutes and the Affiliated Hospital of Qingdao University, Qingdao, China.ORCID http://orcid.org/0000-0002-0174-9254
Alicia R MartinAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0241-3522
Julien BryoisDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4747-2166
Xixian MaKey Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Helena GasparSocial Genetic and Developmental Psychiatry, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5540-2707
Masashi IkedaDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
Beben BenyaminAustralian Centre for Precision Health, School of Health Sciences, University of South Australia Cancer Research Institute, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0001-5608-2293
Brielin C BrownData Science Institute, Columbia University, New York, NY, USA.
Ruize LiuAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Wei ZhouKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Lili GuanPeking University Sixth Hospital and Institute of Mental Health, Beijing, China.
Yoichiro KamataniLaboratory of Complex Trait Genomics, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Sung-Wan KimDepartment of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Agung A A A KusumawardhaniDepartment of Psychiatry, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia.
Chih-Min LiuDepartment of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0001-7016-8990
Hong MaPeking University Sixth Hospital and Institute of Mental Health, Beijing, China.
Sathish PeriyasamyQueensland Brain Institute The University of Queensland, Brisbane, Queensland, Australia.ORCID http://orcid.org/0000-0002-8132-5717
Atsushi TakahashiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-7099-8767
Zhida XuDepartment of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
Hao YuPeking University Sixth Hospital and Institute of Mental Health, Beijing, China.ORCID http://orcid.org/0000-0002-9785-8489
Feng ZhuCenter for Translational Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Schizophrenia Working Group of the Psychiatric Genomics Consortium
Indonesia Schizophrenia Consortium
Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN)
Wei J ChenDepartment of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.
Stephen FaraoneThe State University of New York, Syracuse, NY, USA.
Stephen J GlattPsychiatric Genetic Epidemiology and Neurobiology Laboratory (PsychGENe lab), Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA.
Lin HeKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Steven E HymanStanley Center for Psychiatric Research, the Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Hai-Gwo HwuDepartment of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan.
Steven A McCarrollStanley Center for Psychiatric Research, the Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Benjamin M NealeAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Pamela SklarGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dieter B WildenauerUniversity of Western Australia, Perth, Western Australia, Australia.
Xin YuPeking University Sixth Hospital and Institute of Mental Health, Beijing, China.
Dai ZhangPeking University Sixth Hospital and Institute of Mental Health, Beijing, China.
Bryan J MowryQueensland Brain Institute The University of Queensland, Brisbane, Queensland, Australia.
Jimmy LeeInstitute of Mental Health, Singapore, Singapore.
Peter HolmansMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine , Cardiff University, Cardiff, UK.
Shuhua XuKey Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Patrick F SullivanDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stephan RipkeAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Michael C O'DonovanMRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, School of Medicine , Cardiff University, Cardiff, UK.
Mark J DalyAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Shengying QinKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) and the Collaborative Innovation Center for Brain Science, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
Pak ShamState Key Laboratory of Brain and Cognitive Sciences, Centre for Genomic Sciences, The University of Hong Kong, Hong Kong, China.
Nakao IwataDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.
Kyung S HongDepartment of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea.
Sibylle G SchwabMolecular Horizons and School of Chemistry and Molecular Bioscience, University of Wollongong, Wollongong, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9370-9080
Weihua YuePeking University Sixth Hospital and Institute of Mental Health, Beijing, China. dryue@bjmu.edu.cn.
Ming TsuangCenter for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, San Diego, CA, USA. mtsuang@ucsd.edu.
Jianjun LiuHuman Genetics, Genome Institute of Singapore, Singapore, Singapore. liuj3@gis.astar.edu.sg.
Xiancang MaDepartment of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. maxiancang@163.com.
René S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. rene.kahn@mssm.edu.
Yongyong ShiBio-X Institutes, Shanghai Jiao Tong University and Research Division, Institute of Mental Health Singapore, Singapore, Singapore. shiyongyong@gmail.com.
Hailiang HuangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. hhuang@broadinstitute.org.
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M1/2 Expanding Rapid Ascertainment Networks Of Schizophrenia Families In TaiwanR01MH085560 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TSUANG, MING T. · 2008 to 2012
$5.8M2/7 Psychiatric Genomics Consortium: Finding Actionable VariationU01MH109539 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI DALY, MARK JOSEPH · 2016 to 2020
$4.7M7/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109532 · NIMH · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2016 to 2020
$3.1M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9M3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7M1/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109528 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2016 to 2020
$2.5M2/2-Expanding Rapid Ascertainment Networks Of Schizophrenia Families In TaiwanR01MH085521 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI GLATT, STEPHEN J · 2008 to 2012
$1.5MGenetics and gene regulation in the inflammatory bowel diseasesK01DK114379 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI HUANG, HAILIANG · 2017 to 2021
$632kMitochondrial-Nuclear Genetic Interactions in Spontaneous HCV ClearanceR21AI139012 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HULGAN, TODD M, KIM, ARTHUR Y · 2018 to 2019
$494kGeneralizing polygenic risk prediction methods across populations for insights into psychiatric diseaseK99MH117229 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN, ALICIA · 2018 to 2019
$262kMedical Research Council G0800509Medical Research Council MR/L010305/1Medical Research Council MR/P005748/1NHGRI NIH HHS U54 HG003067NIAID NIH HHS R21 AI139012NIDDK NIH HHS K01 DK114379NIMH NIH HHS K99 MH117229NIMH NIH HHS R01 MH085521NIMH NIH HHS R01 MH085560NIMH NIH HHS U01 MH109514NIMH NIH HHS U01 MH109528NIMH NIH HHS U01 MH109532NIMH NIH HHS U01 MH109536NIMH NIH HHS U01 MH109539
Abstract
Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.
Indexed as
Polymorphism, Single NucleotideAsia, EasternAsian PeopleCase-Control StudiesGenetics, PopulationGenome-Wide Association StudyHumansSchizophreniaWhite People
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