ArticleNature genetics2019
Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells.
Article in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
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- Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy.Circulation. Heart failure · 2026Article
- Non-genetic neuromodulation with graphene optoelectronic actuators for disease models, stem cell maturation, and biohybrid robotics.Nature communications · 2025Article
- Cell Adhesion Molecule Protocadherin-γC5 Ameliorates Aβ Plaque Pathogenesis by Modulating Astrocyte Function in Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- DNA methylation governs the sensitivity of repeats to restriction by the HUSH-MORC2 corepressor.Nature communications · 2024Article
- Histone methyltransferase SETD2 is required for proper hippocampal lamination and neuronal maturation.Molecular biology of the cell · 2024Article
- CDCA7-associated global aberrant DNA hypomethylation translates to localized, tissue-specific transcriptional responses.Science advances · 2024Article
- Outward-oriented sites within clustered CTCF boundaries are key for intra-TAD chromatin interactions and gene regulation.Nature communications · 2023Article
- Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality.iScience · 2023Article
- DNA methylation profiling in Trisomy 21 females with and without breast cancer.Frontiers in oncology · 2023Article
- Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes.Nature communications · 2022Article
- Article
- The role of epigenetic modifications, long-range contacts, enhancers and topologically associating domains in the regulation of glioma grade-specific genes.Scientific reports · 2021Article
- Co-Regulated Genes and Gene Clusters.Genes · 2021Review
- Analysis of Brugada syndrome loci reveals that fine-mapping clustered GWAS hits enhances the annotation of disease-relevant variants.Cell reports. Medicine · 2021Article
- Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states.Nature communications · 2021Article
- Wiring the Brain by Clustered Protocadherin Neural Codes.Neuroscience bulletin · 2021Review
- Gene Families With Stochastic Exclusive Gene Choice Underlie Cell Adhesion in Mammalian Cells.Frontiers in cell and developmental biology · 2021Article
- The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases.Current opinion in genetics & development · 2020Review
- Dedifferentiation and neuronal repression define familial Alzheimer's disease.Science advances · 2020Article
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Authors and funding
22 authors at 6 institutions in 4 countries.
Funding
Abstract
In the mammalian genome, the clustered protocadherin (cPCDH) locus provides a paradigm for stochastic gene expression with the potential to generate a unique cPCDH combination in every neuron. Here we report a chromatin-based mechanism that emerges during the transition from the naive to the primed states of cell pluripotency and reduces, by orders of magnitude, the combinatorial potential in the human cPCDH locus. This mechanism selectively increases the frequency of stochastic selection of a small subset of cPCDH genes after neuronal differentiation in monolayers, 10-month-old cortical organoids and engrafted cells in the spinal cords of rats. Signs of these frequent selections can be observed in the brain throughout fetal development and disappear after birth, except in conditions of delayed maturation such as Down's syndrome. We therefore propose that a pattern of limited cPCDH-gene expression diversity is maintained while human neurons still retain fetal-like levels of maturation.
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