ArticleNature nanotechnology2019
Catalytic site-selective substrate processing within a tubular nanoreactor.
Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Biosensing With Nanofluidics.Exploration (Beijing, China) · 2026Review
- Understanding single-molecule reactions using nanopore-based techniques.Nature chemistry · 2025Review
- Designer topological-single-atom catalysts with site-specific selectivity.Nature communications · 2025Article
- Review
- Remodeling nanodroplets into hierarchical mesoporous silica nanoreactors with multiple chambers.Nature communications · 2022Article
- A reversibly gated protein-transporting membrane channel made of DNA.Nature communications · 2022Article
- Profiling single-molecule reaction kinetics under nanopore confinement.Chemical science · 2022Article
- Triggered Assembly of a DNA-Based Membrane Channel.Journal of the American Chemical Society · 2022Article
- Towards explicit regulating-ion-transport: nanochannels with only function-elements at outer-surface.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Chemists have long sought the ability to modify molecules precisely when presented with several sites of similar reactivity. We reasoned that the confinement of substrates within nanostructures might permit site-selective reactions unachievable in bulk solution, even with sophisticated reagents. In particular, the stretching and alignment of polymers within nanotubes might allow site-specific cleavage or modification. To explore this proposition, macromolecular disulfide substrates were elongated within members of a collection of tubular protein nanoreactors, which contained cysteine residues positioned at different locations along the length of each tube. For each nanoreactor, we defined the reactive location by using a set of polymer substrates (site-selectivity) and which of the two sulfur atoms was attacked (regioselectivity), and found that disulfide interchange occurs with atomic precision. Our strategy has potential for the selective processing of a wide variety of biomacromolecules, and the chemistry and substrates might be generalized yet further by using alternative nanotubes.
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Registered trials
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