Evidence map›Paper›PMID 31740767›Full record

ArticleBone marrow transplantation2020

Transplant center characteristics and survival after allogeneic hematopoietic cell transplantation in adults.

Navneet S Majhail, Lih-Wen Mau, Pintip Chitphakdithai, Ellen M Denzen, Steven Joffe, Stephanie J Lee, Charles F LeMaistre, Fausto Loberiza, Susan K Parsons, Ramona Repaczki-Jones and 5 more

Abstract read
In one paragraph

Article in Bone marrow transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Barriers to Hematopoietic Cell Transplantation for Adults in the United States: A Systematic Review with a Focus on Age.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2020
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Navneet S MajhailBlood & Marrow Transplant Program, Cleveland Clinic, Cleveland, OH, USA. majhain@ccf.org.ORCID http://orcid.org/0000-0001-7082-891X
Lih-Wen MauNational Marrow Donor Program, Minneapolis, MN, USA.
Pintip ChitphakdithaiCenter for International Blood and Marrow Transplant Research, Minneapolis, MN, USA.
Ellen M DenzenNational Marrow Donor Program, Minneapolis, MN, USA.
Steven JoffePerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Stephanie J LeeClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2600-6390
Charles F LeMaistreSarah Cannon, Nashville, TN, USA.
Fausto LoberizaPfizer Oncology, Omaha, NE, USA.
Susan K ParsonsCenter for Health Solutions, Tufts Medical Center, Boston, MA, USA.
Ramona Repaczki-JonesBlood and Marrow Transplant Program, Moffitt Cancer Center, Tampa, FL, USA.
Pam RobinettNational Marrow Donor Program, Minneapolis, MN, USA.
J Douglas RizzoCenter for International Blood and Marrow Transplant Research, Milwaukee, WI, USA.
Elizabeth MurphyNational Marrow Donor Program, Minneapolis, MN, USA.
Brent LoganCenter for International Blood and Marrow Transplant Research, Milwaukee, WI, USA.
Jennifer Le-RademacherDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-2234-7430

Funding

Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069294
6 · The paper itself

Abstract

Allogeneic hematopoietic cell transplantation (alloHCT) is a highly specialized procedure. We surveyed adult transplant centers in the United States (US) and then used data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) (2008-2010) to evaluate associations of center volume, infrastructure, and care delivery models with survival post alloHCT. Based on their 2010 alloHCT volume, centers were categorized as low-volume (≤40 alloHCTs; N = 42 centers, 1900 recipients) or high-volume (>40 alloHCTs; N = 41 centers, 9637 recipients). 100-day survival was 86% (95% CI, 85-87%) in high-volume compared with 83% (95% CI, 81-85%) in low-volume centers (difference 3%; P < 0.001). One-year survival was 62% (95% CI, 61-63%) and 56% (95% CI, 54-58%), respectively (difference 6%; P < 0.001). Logistic regression analyses adjusted for patient and center characteristics; alloHCT at high-volume centers (odds ratio [OR] 1.32; P < 0.001) and presence of a survivorship program dedicated to HCT recipients (OR 1.23; P = 0.009) were associated with favorable 1-year survival compared to low-volume centers. Similar findings were observed in a CIBMTR validation cohort (2012-2014); high-volume centers had better 1-year survival (OR 1.24, P < 0.001). Among US adult transplant centers, alloHCT at high-volume centers and at centers with survivorship programs is associated with higher 1-year survival.

Indexed as

Hematopoietic Stem Cell TransplantationTransplantsAdultCohort StudiesHumansTransplantation ConditioningTransplantation, HomologousUnited States

Identifiers

PMID31740767
PMCPMC7202970

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.