Evidence map›Paper›PMID 31740754›Full record

ArticleMolecular psychiatry2021

C-reactive protein is associated with cognitive performance in a large cohort of euthymic patients with bipolar disorder.

C E Millett, M Perez-Rodriguez, M Shanahan, E Larsen, H S Yamamoto, C Bukowski, R Fichorova, K E Burdick

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Bipolar disorder.Lancet (London, England) · 2025
    Review
  9. Review
  10. Cognition in Bipolar Disorder: An Update for Clinicians.Focus (American Psychiatric Publishing) · 2023
    Review
  11. Rethinking Immunity and Cognition in Clinical High Risk for Psychosis.Current topics in behavioral neurosciences · 2023
    Article
  12. Article
  13. Article
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

C E MillettMood and Psychosis Research Program, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
M Perez-RodriguezIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5137-1993
M ShanahanMood and Psychosis Research Program, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA.
E LarsenIcahn School of Medicine at Mount Sinai, New York, NY, USA.
H S YamamotoLaboratory of Genital Tract Biology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
C BukowskiLaboratory of Genital Tract Biology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
R FichorovaLaboratory of Genital Tract Biology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
K E BurdickMood and Psychosis Research Program, Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA. kburdick1@bwh.harvard.edu.
Brigham and Women's Hospital · USIcahn School of Medicine at Mount Sinai · US

Funding

Understanding the Neurocognitive Heterogeneity in Bipolar DisorderR01MH100125 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BURDICK, KATHERINE ELIZABETH · 2013 to 2017
$2.1M
NIMH NIH HHS R01 MH100125
6 · The paper itself

Abstract

Data support the notion that 40-60% of patients with bipolar disorder (BD) have neurocognitive deficits. It is increasingly accepted that functioning in BD is negatively impacted by these deficits, yet they have not been a successful target for treatment. The biomarkers that predict cognitive deficits in BD are largely unknown, however recent evidence suggests that inflammation may be associated with poorer cognitive outcomes in BD. We measured C-reactive protein (CRP), a marker of systemic inflammation and risk of inflammatory disease, in 222 euthymic BD patients and 52 healthy controls. Within the patient sample, using multivariate analyses of covariance (MANCOVA) we compared cognitive performance of those with high CRP (≥5 mg/L) versus the remaining subjects (<5 mg/L) on a battery of cognitive tests. We evaluated relationships with several other relevant clinical features. We also examined the role of CRP in cognitive decline using a proxy cognitive decline metric, defined as the difference between premorbid and current IQ estimates, in a logistic regression analysis. Approximately 80% of our sample were BD-I, and the remainder were BD-II and 42.6% of our sample had a history of psychosis. We found a statistically significant effect of CRP on cognitive performance on a broad range of tests; participants with CRP ≥ 5 mg/L had worse performance on several measures of executive functioning, MATRICS processing speed and MATRICS reasoning and problem solving relative to those with lower CRP. We also identified CRP as a significant positive predictor of proxy cognitive decline. Our results indicate that elevated CRP is associated with a broad cognitive dysfunction in affectively remitted BD patients. These results may point to a subgroup of patients who might benefit from treatments to reduce inflammation.

Indexed as

Bipolar DisorderCognition DisordersCognitionC-Reactive ProteinHumansNeuropsychological TestsC-Reactive Protein

Identifiers

PMID31740754
OpenAlexW2985781204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.