ArticleScientific reports2019
Identification of novel predictive factors for post surgical corneal haze.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
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- Assessing Changes in Corneal Densitometry in Patients After Small Incision Lenticule Extraction (SMILE).Cureus · 2024Article
- Transepithelial Photorefractive Keratectomy-Review.Vision (Basel, Switzerland) · 2024Review
- Anterior segment inflammation and its association with dry eye parameters following myopic SMILE and FS-LASIK.Annals of medicine · 2023Observational
- Patient stratification using point of care biomarkers in dry eye disease.Indian journal of ophthalmology · 2023Article
- Corneal stromal repair and regeneration.Progress in retinal and eye research · 2022Review
- Safety and efficacy of combination of suberoylamilide hydroxyamic acid and mitomycin C in reducing pro-fibrotic changes in human corneal epithelial cells.Scientific reports · 2021Article
- Photorefractive keratectomy (PRK) Prediction, Examination, tReatment, Follow-up, Evaluation, Chronic Treatment (PERFECT) protocol - A new algorithmic approach for managing post PRK haze.Indian journal of ophthalmology · 2020Article
- Algorithmic approach to diagnosis and management of post-refractive surgery dry eye disease.Indian journal of ophthalmology · 2020Review
- Multimodal imaging for refractive surgery:Indian journal of ophthalmology · 2020Article
- Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 is a diagnostic and prognostic biomarker for hepatocellular carcinoma.World journal of clinical cases · 2020Article
- Establishing a Porcine Eye Model for Manual Sub-Bowman Layer Photorefractive Keratomileusis.Journal of ophthalmology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular factors altered in corneas that develop haze post refractive surgery have been described, but pre-existing factors that predispose clinically normal corneas to aberrant fibrosis post surgery and the role of the corneal epithelium remains unknown. We analyzed the global gene expression in epithelium collected intraoperatively from subjects undergoing photorefractive keratectomy. Subjects were grouped into those that developed haze 12 months post surgery (n = 6 eyes; haze predisposed) and those that did not develop haze in a similar follow up duration (n = 11 eyes; controls). Ontological analysis of 1100 upregulated and 1780 downregulated genes in the haze predisposed group revealed alterations in pathways associated with inflammation, wnt signaling, oxidative stress, nerve functions and extra cellular matrix remodeling. Novel factors such as PREX1, WNT3A, SOX17, GABRA1and PXDN were found to be significantly altered in haze predisposed subjects and those with active haze(n = 3), indicating their pro-fibrotic role. PREX1 was significantly upregulated in haze predisposed subjects. Ectopic expression of PREX1 in cultured human corneal epithelial cells enhanced their rate of wound healing while its ablation using shRNA reduced healing compared to matched controls. Recombinant TGFβ treatment in PREX1 overexpressing corneal cells led to enhanced αSMA expression and Vimentin phosphorylation while the converse was true for shPREX1 expressing cells. Our data identify a few novel factors in the corneal epithelium that may define a patient's risk to developing post refractive corneal haze.
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