ArticleScientific reports2019
Gut bacteria of Cuora amboinensis (turtle) produce broad-spectrum antibacterial molecules.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
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- Size-dependent effects of the intestinal microbiota in juvenile Chinese alligators: implications for species protection.Frontiers in zoology · 2025Article
- Insights into the Gut Microbiome of the South American Leaf-Toed Gecko (Microorganisms · 2024Article
- One pot synthesis of 5-hydroxyalkylated thiadiazine thiones: Implication in pain management and bactericidal properties.Heliyon · 2024Article
- Herptile gut microbiomes: a natural system to study multi-kingdom interactions between filamentous fungi and bacteria.mSphere · 2024Article
- Animal Microbiomes as a Source of Novel Antibiotic-Producing Strains.International journal of molecular sciences · 2023Review
- Selected Gut Bacteria from Water Monitor Lizard Exhibit Effects against PathogenicMicroorganisms · 2023Article
- Antibacterial Properties of Ethacridine Lactate and Sulfmethoxazole Loaded Functionalized Graphene Oxide Nanocomposites.Antibiotics (Basel, Switzerland) · 2023Article
- Enhancing efficacy of existing antibacterials against selected multiple drug resistant bacteria using cinnamic acid-coated magnetic iron oxide and mesoporous silica nanoparticles.Pathogens and global health · 2022Article
- Antiamoebic Activity of Imidazothiazole Derivatives against Opportunistic PathogenAntibiotics (Basel, Switzerland) · 2022Article
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- Novel Sources of Bioactive Molecules: Gut Microbiome of Species Routinely Exposed to Microorganisms.Veterinary sciences · 2022Review
- Hesperidin-, Curcumin-, and Amphotericin B- Based Nano-Formulations as Potential Antibacterials.Antibiotics (Basel, Switzerland) · 2022Article
- Antiamoebic Properties of Metabolites againstAntibiotics (Basel, Switzerland) · 2022Article
- Antibacterial effects of octadecyl trimethylammonium micelle-clay complex against bacterial eye pathogens: potential as a contact lens disinfectant.International ophthalmology · 2022Article
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- Moxifloxacin and Sulfamethoxazole-Based Nanocarriers Exhibit Potent Antibacterial Activities.Antibiotics (Basel, Switzerland) · 2021Article
- Zinc oxide nanoparticles conjugated with clinically-approved medicines as potential antibacterial molecules.AMB Express · 2021Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance is a major threat to human health, hence there is an urgent need to discover antibacterial molecule(s). Previously, we hypothesized that microbial gut flora of animals are a potential source of antibacterial molecules. Among various animals, Cuora amboinensis (turtle) represents an important reptile species living in diverse ecological environments and feed on organic waste and terrestrial organisms and have been used in folk medicine. The purpose of this study was to mine turtle's gut bacteria for potential antibacterial molecule(s). Several bacteria were isolated from the turtle gut and their conditioned media were prepared. Conditioned media showed potent antibacterial activity against several Gram-positive (Bacillus cereus, Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus) and Gram-negative (neuropathogenic Escherichia coli K1, Serratia marcescens, Pseudomonas aeruginosa, Salmonella enterica and Klebsiella pneumoniae) pathogenic bacteria. Conditioned media-mediated bactericidal activity was heat-resistant when treated at 95°C for 10 min. By measuring Lactate dehydrogenase release, the results showed that conditioned media had no effect on human cell viability. Tandem Mass Spectrometric analysis revealed the presence of various secondary metabolites, i.e., a series of known as well as novel N-acyl-homoserine lactones, several homologues of 4-hydroxy-2-alkylquinolines, and rhamnolipids, which are the signature metabolites of Pseudomonas species. These findings are significant and provide the basis for rational development of therapeutic interventions against bacterial infections.
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