Evidence map›Paper›PMID 31740609›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Dichotomous regulation of group 3 innate lymphoid cells by nongastric

John W Bostick, Yetao Wang, Zeli Shen, Yong Ge, Jeffrey Brown, Zong-Ming E Chen, Mansour Mohamadzadeh, James G Fox, Liang Zhou

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Food science & nutrition · 2025
    Article
  4. Review
  5. Group 3 innate lymphoid cells in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2024
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. ILCs-Crucial Players in Enteric Infectious Diseases.International journal of molecular sciences · 2022
    Review
  16. The Role of Gut and Lung Microbiota in Susceptibility to Tuberculosis.International journal of environmental research and public health · 2021
    Review
  17. Article
  18. Article
  19. Gut Microbiota-Host Interactions in Inborn Errors of Immunity.International journal of molecular sciences · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

John W BostickDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608.
Yetao WangDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Zeli ShenDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139.
Yong GeDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608.
Jeffrey BrownDepartment of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Northwestern Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611.
Zong-Ming E ChenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905.
Mansour MohamadzadehDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608.
James G FoxDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139.
Liang ZhouDepartment of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608; liangzhou497@ufl.edu.
University of Florida · USNorthwestern University · USCornell University · USLurie Children's Hospital · USMassachusetts Institute of Technology · USMayo Clinic · US

Funding

Regulation of Gut Innate Lymphoid Cells by AhrR01AI132391 · NIAID · UNIVERSITY OF FLORIDA · PI Liang Zhou · 2017 to 2026
$4.8M
ROLE OF AHR IN T LYMPHOCYTE DEVELOPMENT AND FUNCTIONR01DK105562 · NIDDK · UNIVERSITY OF FLORIDA · PI ZHOU, LIANG · 2015 to 2019
$1.8M
Sony Cell Sorter SH800 SystemS10OD021676 · OD · UNIVERSITY OF FLORIDA · PI PASCUAL, DAVID W · 2016 to 2016
$296k
NIAID NIH HHS R01 AI132391NIDDK NIH HHS R01 DK105562NIH HHS S10 OD021676
6 · The paper itself

Abstract

Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two

Indexed as

AnimalsCitrobacter rodentiumColitisDextran SulfateDisease Models, AnimalEnterobacteriaceae InfectionsFemaleGastrointestinal MicrobiomeHelicobacterHomeodomain ProteinsHost Microbial InteractionsHumansImmune ToleranceImmunity, InnateImmunity, MucosalIntestinal MucosaDextran SulfateHomeodomain ProteinsMembrane GlycoproteinsNuclear Receptor Subfamily 1, Group F, Member 3P-selectin ligand proteinRAG-1 proteinT-bet Transcription FactorT-Box Domain ProteinsHelicobacterhost–microbiomeILCinflammation

Identifiers

PMID31740609
PMCPMC6900599
OpenAlexW2991077228

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.