Evidence map›Paper›PMID 31740563›Full record

ArticleLife science alliance2019

ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user's research.

Francisco Ramos-Martín, Thibault Annaval, Sébastien Buchoux, Catherine Sarazin, Nicola D'Amelio

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. AbAMPdb: a database of Acinetobacter baumannii specific antimicrobial peptides.Database : the journal of biological databases and curation · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Antimicrobial Peptides: A Potent Alternative to Antibiotics.Antibiotics (Basel, Switzerland) · 2021
    Review
  15. Review
  16. Article
  17. Article
  18. Frontiers in molecular biosciences · 2021
    Review
  19. Article
  20. Monitoring the Site-Specific Solid-State NMR Data in Oligopeptides.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Francisco Ramos-MartínGénie Enzymatique et Cellulaire, Unité Mixte de Recherche 7025, Centre National de la Recherche Scientifique, Université de Picardie Jules Verne, Amiens, France francisco.ramos@u-picardie.fr.
Thibault AnnavalGénie Enzymatique et Cellulaire, Unité Mixte de Recherche 7025, Centre National de la Recherche Scientifique, Université de Picardie Jules Verne, Amiens, France.
Sébastien BuchouxGénie Enzymatique et Cellulaire, Unité Mixte de Recherche 7025, Centre National de la Recherche Scientifique, Université de Picardie Jules Verne, Amiens, France.
Catherine SarazinGénie Enzymatique et Cellulaire, Unité Mixte de Recherche 7025, Centre National de la Recherche Scientifique, Université de Picardie Jules Verne, Amiens, France.
Nicola D'AmelioGénie Enzymatique et Cellulaire, Unité Mixte de Recherche 7025, Centre National de la Recherche Scientifique, Université de Picardie Jules Verne, Amiens, France nicola.damelio@u-picardie.fr.ORCID 0000-0002-4400-2222
Université de Picardie Jules Verne · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are part of the innate immune response to pathogens in all of the kingdoms of life. They have received significant attention because of their extraordinary variety of activities, in particular, as candidate drugs against the threat of super-bacteria. A systematic study of the relation between the sequence and the mechanism of action is urgently needed, given the thousands of sequences already in multiple web resources. ADAPTABLE web platform (http://gec.u-picardie.fr/adaptable) introduces the concept of "property alignment" to create families of property and sequence-related peptides (SR families). This feature provides the researcher with a tool to select those AMPs meaningful to their research from among more than 40,000 nonredundant sequences. Selectable properties include the target organism and experimental activity concentration, allowing selection of peptides with multiple simultaneous actions. This is made possible by ADAPTABLE because it not only merges sequences of AMP databases but also merges their data, thereby standardizing values and handling non-proteinogenic amino acids. In this unified platform, SR families allow the creation of peptide scaffolds based on common traits in peptides with similar activity, independently of their source.

Indexed as

Amino Acid SequenceAnti-Infective AgentsAntimicrobial Cationic PeptidesBacteriaDatabases, FactualDatabases, ProteinPeptidesAnti-Infective AgentsAntimicrobial Cationic PeptidesPeptides

Identifiers

PMID31740563
PMCPMC6864362
OpenAlexW2991176535

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.