Evidence map›Paper›PMID 31740487›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8

Vinay S Mahajan, Ezana Demissie, Faisal Alsufyani, Sudha Kumari, Grace J Yuen, Vinayak Viswanadham, Andrew Huang, Johnson Q Tran, James J Moon, Darrell J Irvine and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Insights from DOCK2 in cell function and pathophysiology.Frontiers in molecular biosciences · 2022
    Review
  8. Review
  9. Signals for antigen-independent differentiation of memory CD8Cellular and molecular life sciences : CMLS · 2021
    Review
  10. T Cell Reprogramming Against Cancer.Methods in molecular biology (Clifton, N.J.) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vinay S MahajanRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Ezana DemissieRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Faisal AlsufyaniRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Sudha KumariThe Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139; and.ORCID 0000-0001-7082-2825
Grace J YuenRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.ORCID 0000-0002-3253-9575
Vinayak ViswanadhamRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Andrew HuangRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.ORCID 0000-0003-2131-9398
Johnson Q TranCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129.ORCID 0000-0002-5263-6321
James J MoonCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129.ORCID 0000-0001-8246-931X
Darrell J IrvineRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139.
Shiv PillaiRagon Institute of MGH, MIT and Harvard, Cambridge, MA 02139; pillai@helix.mgh.harvard.edu.

Funding

The importance of the IgG4 glycome in IgG4-related disease(s)U19AI110495 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SHIV Subramaniam PILLAI · 2014 to 2026
$7.9M
Studies on Peripheral B Lymphocyte DevelopmentR01AI064930 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PILLAI, SHIV SUBRAMANIAM · 2006 to 2016
$3.9M
Self Antigen Specific CD4 Positive T cellsR01AI107020 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOON, JAMES J · 2014 to 2018
$2.1M
Pathogenesis of IgG4 related diseaseK08AI113163 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MAHAJAN, VINAY SUBHASH · 2014 to 2018
$953k
CD4+ T cell Tolerance to Enteric Commensal BacteriaR21AI124143 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MOON, JAMES J · 2017 to 2018
$448k
NIAID NIH HHS K08 AI113163NIAID NIH HHS R01 AI064930NIAID NIH HHS R01 AI107020NIAID NIH HHS R21 AI124143NIAID NIH HHS U19 AI110495
6 · The paper itself

Abstract

The control of cytoskeletal dynamics by dedicator of cytokinesis 2 (DOCK2), a hematopoietic cell-specific actin effector protein, has been implicated in TCR signaling and T cell migration. Biallelic mutations in

Indexed as

AnimalsCD8-Positive T-LymphocytesGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHomeodomain ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Antigen, T-CellDOCK2 protein, mouseGTPase-Activating ProteinsGuanine Nucleotide Exchange FactorsHomeodomain ProteinsRAG-1 proteinReceptors, Antigen, T-Cell

Identifiers

PMID31740487
PMCPMC6920543

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.