Evidence map›Paper›PMID 31740484›Full record

ReviewJournal of neurology, neurosurgery, and psychiatry2020

Case for a new corticosteroid treatment trial in optic neuritis: review of updated evidence.

Axel Petzold, Tasanee Braithwaite, Bob W van Oosten, Lisanne Balk, Elena H Martinez-Lapiscina, Russell Wheeler, Nils Wiegerinck, Christiaan Waters, Gordon T Plant

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07704294 (Early Prediction of Outcomes Following Optic Neuritis), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07704294 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Early Prediction of Outcomes Following Optic Neuritis: Development and Acceptability of a Prognostic Tool (MS Predictor)

TypeobservationalSponsorKing's College LondonRan2026 to 2027Enrolled180ConditionsOptic Neuritis, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related DisordersArmsNo Intervention: Observational Cohort
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Treatment of post-vaccination optic neuritis: implications from the global SARS-CoV-2 vaccination effort.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Review
  11. Article
  12. Article
  13. An update on optic neuritis.Journal of neurology · 2023
    Article
  14. Treatment and Relapse Prevention of Typical and Atypical Optic Neuritis.International journal of molecular sciences · 2022
    Review
  15. Review
  16. Article
  17. Update on Optic Neuritis: An International View.Neuro-ophthalmology (Aeolus Press) · 2022
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Axel PetzoldExpertise Centrum Neuro-ophthalmology, Departments of Neurology & Ophthalmology, Amsterdam UMC, Amsterdam, The Netherlands a.petzold@ucl.ac.uk.ORCID 0000-0002-0344-9749
Tasanee BraithwaiteNeuro-ophthalmology, Moorfields Eye Hospital and The National Hospital for Neurology & Neurosurgery, London, UK.
Bob W van OostenAmsterdam UMC, VUMC Campus, Amsterdam, The Netherlands.
Lisanne BalkNeurology, VU University Medical Center, Amsterdam, The Netherlands.
Elena H Martinez-LapiscinaCenter of Neuroimmunology and Service of Neurology, Clinic Barcelona Hospital University, Barcelona, Spain.ORCID 0000-0003-4272-0826
Russell WheelerERN-EYE, Bordeaux, UK.
Nils Wiegerinck)Patient Organisation (Neuro-ophthalmology), Lisbon, Portugal.
Christiaan WatersNeuro-ophthalmologie Vereniging Nederland (KvK nummer 66260140), Amsterdam, Netherlands.
Gordon T Plant,National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, St. Thomas Hospital, Moorfields Eye Hospital, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adrenal Cortex HormonesDrug ApprovalHumansOptic NeuritisPrognosisTreatment OutcomeAdrenal Cortex Hormonesimmunologyneurochemistryneuro-ophthalmologyophthalmologyvision

Identifiers

PMID31740484
PMCPMC6952848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.