Evidence map›Paper›PMID 31740451›Full record

ArticleGenetics2020

A PUF Hub Drives Self-Renewal in

Kimberly A Haupt, Kimberley T Law, Amy L Enright, Charlotte R Kanzler, Heaji Shin, Marvin Wickens, Judith Kimble

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. RNA (New York, N.Y.) · 2025
    Article
  6. Article
  7. Article
  8. A higher order PUF complex is central to regulation ofbioRxiv : the preprint server for biology · 2024
    Article
  9. Biology · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Functional significance of PUF partnerships inbioRxiv : the preprint server for biology · 2023
    Article
  17. Analysis of the C. elegans Germline Stem Cell Pool.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kimberly A HauptDepartment of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706.ORCID 0000-0003-1109-3129
Kimberley T LawDepartment of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706.
Amy L EnrightDepartment of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706.
Charlotte R KanzlerDepartment of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706.
Heaji ShinDepartment of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706.ORCID 0000-0001-5208-5999
Marvin WickensDepartment of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706.ORCID 0000-0002-0593-5740
Judith KimbleDepartment of Biochemistry, University of Wisconsin-Madison, Wisconsin 53706 jekimble@wisc.edu.ORCID 0000-0001-5622-2073
University of Wisconsin–Madison · US

Funding

FUNCTION OF POLY(A) AND 3'UTRSR01GM050942 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WICKENS, MARVIN P. · 1994 to 2020
$8.3M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular regulation of germline developmentR01GM134119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KIMBLE, JUDITH · 2019 to 2022
$2.2M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM050942NIGMS NIH HHS R01 GM134119NIH HHS P40 OD010440
6 · The paper itself

Abstract

Stem cell regulation relies on extrinsic signaling from a niche plus intrinsic factors that respond and drive self-renewal within stem cells.

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell DifferentiationCell ProliferationCell Self RenewalEmbryo, NonmammalianEpistasis, GeneticGerm CellsMaleMutationRNA-Binding ProteinsStem CellsCaenorhabditis elegans Proteinsfem-3-binding protein, C elegansRNA-Binding ProteinsFBFPUF-11PUF-3redundancystem cell regulatory network

Identifiers

PMID31740451
PMCPMC6944405
OpenAlexW2989950764

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.