ArticleNeuroImage2020
Integrated VASO and perfusion contrast: A new tool for laminar functional MRI.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Magnetization transfer weighted EPI facilitates cortical depth determination in native fMRI space.NeuroImage · 2021Trial
- Article
- Impact of thermal and physiological denoising on laminar functional connectivity.Scientific reports · 2026Article
- The laminar pattern of proprioceptive activation in human primary motor cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Multilayer network analysis across cortical depths in 7-T resting-state fMRI.Network neuroscience (Cambridge, Mass.) · 2025Article
- Blood nulling versus tissue suppression: Enhancing integrated VASO and perfusion (VAPER) contrast for laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Revealing layer-specific cortical activity in human M1 using high-resolution line-scanning fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Multilayer Network Analysis across Cortical Depths in Resting-State 7T fMRI.bioRxiv : the preprint server for biology · 2024Article
- Direct angiographic comparison of different velocity-selective saturation, inversion, and DANTE labeling modules on cerebral arteries.Magnetic resonance in medicine · 2024Article
- Characterisation of laminar and vascular spatiotemporal dynamics of CBV and BOLD signals using VASO and ME-GRE at 7T in humans.bioRxiv : the preprint server for biology · 2024Article
- Exploring methodological frontiers in laminar fMRI.Psychoradiology · 2024Review
- Improving laminar fMRI specificity by reducing macrovascular bias revealed by respiration effects.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Characterisation of laminar and vascular spatiotemporal dynamics of CBV and BOLD signals using VASO and ME-GRE at 7T in humans.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Unlocking near-whole-brain, layer-specific functional connectivity with 3D VAPER fMRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The nature and neurobiology of fear and anxiety: State of the science and opportunities for accelerating discovery.Neuroscience and biobehavioral reviews · 2023Review
- Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex.Human brain mapping · 2023Article
- Cortical depth profiles of auditory and visual 7 T functional MRI responses in human superior temporal areas.Human brain mapping · 2023Article
- Cortical depth-dependent human fMRI of resting-state networks using EPIK.Frontiers in neuroscience · 2023Article
- Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7T: Challenges and capabilities.PloS one · 2023Article
- Recent Technical Developments in ASL: A Review of the State of the Art.Magnetic resonance in medicine · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Earlier research in cats has shown that both cerebral blood volume (CBV) and cerebral blood flow (CBF) can be used to identify layer-dependent fMRI activation with spatial specificity superior to gradient-echo blood-oxygen-level-dependent (BOLD) contrast (Jin and Kim, 2008a). CBF contrast of perfusion fMRI at ultra-high field has not been widely applied in humans to measure laminar activity due to its low sensitivity, while CBV contrast for fMRI using vascular space occupancy (VASO) has been successfully used. However, VASO can be compromised by interference of blood in-flow effects and a temporally limited acquisition window around the blood-nulling time point. Here, we proposed to use DANTE (Delay Alternating with Nutation for Tailored Excitation) pulse trains combined with 3D-EPI to acquire an integrated VASO and perfusion (VAPER) contrast. The signal origin of the VAPER contrast was theoretically evaluated with respect to its CBV and CBF contributions using a four-compartment simulation model. The feasibility of VAPER to measure layer-dependent activity was empirically investigated in human primary motor cortex at 7 T. We demonstrated this new tool, with its highly specified functional layer profile, robust reproducibility, and improved sensitivity, to allow investigation of layer-specific cortical functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.