Evidence map›Paper›PMID 31740228›Full record

ArticleFree radical biology & medicine2020

The thiocyanate analog selenocyanate is a more potent antimicrobial pro-drug that also is selectively detoxified by the host.

Brian J Day, Preston E Bratcher, Joshua D Chandler, Matthew B Kilgore, Elysia Min, John J LiPuma, Robert J Hondal, David P Nichols

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Factors governing the response ofFrontiers in cellular and infection microbiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Halogenation Activity of Mammalian Heme Peroxidases.Antioxidants (Basel, Switzerland) · 2022
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Brian J DayDepartment of Medicine, National Jewish Health, Denver, CO, 80206, USA; Department of Medicine University of Colorado, Aurora, CO, 80045, USA; Department of Pharmaceutical Sciences, University of Colorado, Aurora, CO, 80045, USA. Electronic address: dayb@njhealth.org.
Preston E BratcherDepartment of Pediatrics, National Jewish Health, Denver, CO, 80206, USA.
Joshua D ChandlerDepartment of Pediatrics, Emory University, Atlanta, GA, 30322, USA; Center for CF and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Matthew B KilgoreDepartment of Pediatrics, Emory University, Atlanta, GA, 30322, USA; Center for CF and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, GA, 30322, USA.
Elysia MinDepartment of Medicine, National Jewish Health, Denver, CO, 80206, USA.
John J LiPumaDepartment of Pediatrics, University of Michigan, Ann Arbor, MI, 48109, USA.
Robert J HondalDepartment of Biochemistry, University of Vermont, Burlington, VT, 05405, USA.
David P NicholsDepartment of Pediatrics, University of Washington, Seattle, WA, 98105, USA.
Children's Healthcare of Atlanta · USUniversity of Colorado Denver · USNational Jewish Health · USUniversity of Michigan–Ann Arbor · USUniversity of Vermont · USUniversity of Washington · US

Funding

Selenocyanate as a novel treatment of cystic fibrosis lung diseaseR01HL141146 · NHLBI · NATIONAL JEWISH HEALTH · PI DAY, BRIAN J, HONDAL, ROBERT J · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL141146
6 · The paper itself

Abstract

A hallmark of cystic fibrosis (CF) lung pathology is an increased susceptibility to pulmonary infections. Thiocyanate (

Indexed as

Anti-Infective AgentsMethicillin-Resistant Staphylococcus aureusProdrugsAnimalsAnti-Bacterial AgentsCyanatesHumansSelenium CompoundsThiocyanatesAnti-Bacterial AgentsAnti-Infective AgentsCyanatesProdrugsSelenium Compoundsselenocyanic acidThiocyanatesAntimicrobialsBurkholderia cepacia complexCystic fibrosisHaloperoxidasesHost defenseHypohalous acidsInnate immunityPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID31740228
PMCPMC6951815
OpenAlexW2987127982

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.