ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019
Familial Aggregation and Heritability of Obstructive Sleep Apnea Using Children Probands.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Exploratory Associations of Targeted Genetic Variants with Cephalometric Airway Parameters in Children with Skeletal Class II Sleep-Disordered Breathing Symptoms.Children (Basel, Switzerland) · 2026Article
- Mapping the Genetics of Snoring: Insights into Family Patterns.Current genomics · 2025Review
- Medical Treatment of Obstructive Sleep Apnea in Children.Journal of clinical medicine · 2023Review
- Alternatives to Polysomnography for the Diagnosis of Pediatric Obstructive Sleep Apnea.Diagnostics (Basel, Switzerland) · 2023Review
- Pediatric Sleep Respiratory Disorders: A Narrative Review of Epidemiology and Risk Factors.Children (Basel, Switzerland) · 2023Review
- Unraveling the associations and causalities between glucose metabolism and multiple sleep traits.Frontiers in endocrinology · 2023Article
- The Genetics of Sleep Disorders in Children: A Narrative Review.Brain sciences · 2021Review
- The relationship between sleep-disordered breathing, blood pressure, and urinary cortisol and catecholamines in children.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- Reevaluating Norms for Childhood Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesPrevious studies suggest the presence of familial aggregation of obstructive sleep apnea (OSA) in adults. However, similar data on childhood OSA are limited. This family study aimed to investigate the heritability and familial aggregation of childhood OSA and to examine whether significant differences existed between patients of normal weight and overweight.
methodsChildren aged 6 to 18 years were recruited as probands either from attendants to sleep clinic (with habitual snoring) or the community (without habitual snoring). Parents and siblings of the probands were also invited to participate. All participants underwent nocturnal sleep study.
resultsA total of 229 probands took part, of whom 33 had moderate to severe OSA, 70 had mild disease, and 126 had no OSA. A total of 412 relatives were also recruited. Although the overall heritability of obstructive apnea-hypopnea index (OAHI) was not significant (h² ± SE = 0.03 ± 0.09, P = .37), it was significant in overweight individuals on subgroup analysis (h² ± SE = 0.43 ± 0.24, P = .032). Significant interaction effect of overweight was demonstrated in both heritability and familial aggregation analyses. Bivariate genetic analysis found that the genetic correlation between OAHI and body mass index in overweight individuals (ρ
conclusionsThe differential results of heritability and familial aggregation of OSA in normal weight and overweight subgroups substantiated the recommendation of separating childhood OSA into normal weight and overweight subtypes. In the overweight subgroup, there may be obesity-independent components involved in the genetic variance of OAHI, although a significant proportion of the genetic variance is shared with obesity.
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