Evidence map›Paper›PMID 31739592›Full record

ArticleInternational journal of molecular sciences2019

Celastrol Induces Necroptosis and Ameliorates Inflammation via Targeting Biglycan in Human Gastric Carcinoma.

Dandan Guo, Wei Zhang, Haijie Yang, Jiajia Bi, Yunfei Xie, Binfeng Cheng, Yan Wang, Sujuan Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. The role of celastrol in inflammation and diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. The Role of Cuproptosis Key Factor FDX1 in Gastric Cancer.Current pharmaceutical biotechnology · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Reactive Oxygen Species andAntioxidants (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Gambogic Acid Inhibits Gastric Cancer Cell Proliferation through Necroptosis.Canadian journal of gastroenterology & hepatology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dandan GuoSynthetic Biology Engineering Lab of Henan Province, School of Sciences and Techanology, Xinxiang Medical University, Henan 453003, China.
Wei ZhangCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China.
Haijie YangSchool of Sciences and Technology, Xinxiang Medical University, Henan 453003, China.
Jiajia BiSynthetic Biology Engineering Lab of Henan Province, School of Sciences and Techanology, Xinxiang Medical University, Henan 453003, China.
Yunfei XieSchool of Sciences and Technology, Xinxiang Medical University, Henan 453003, China.
Binfeng ChengSchool of Sciences and Technology, Xinxiang Medical University, Henan 453003, China.
Yan WangSynthetic Biology Engineering Lab of Henan Province, School of Sciences and Techanology, Xinxiang Medical University, Henan 453003, China.
Sujuan ChenSynthetic Biology Engineering Lab of Henan Province, School of Sciences and Techanology, Xinxiang Medical University, Henan 453003, China.
Xinxiang Medical University · CNHenan Institute of Science and Technology · CN

Funding

National Natural Science Foundation of China 31401181, 81771336, U1704186Scientific and Technological Research Project of Henan Provinc 182102311136, 182102311134
6 · The paper itself

Abstract

Celastrol, a triterpene isolated from the root of traditional Chinese medicine

Indexed as

BiglycanBiomarkersCell DeathCell Line, TumorCytokinesGene Expression Regulation, NeoplasticHumansInflammationInflammation MediatorsNecroptosisPentacyclic TriterpenesProtein KinasesStomach NeoplasmsTriterpenesBiglycanBiomarkerscelastrolCytokinesInflammation MediatorsMLKL protein, humanPentacyclic TriterpenesProtein KinasesTriterpenesbiglycancelastrolcytokinesgastric cancer cellsnecroptosis

Identifiers

PMID31739592
PMCPMC6888087
OpenAlexW2988811631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.