Evidence map›Paper›PMID 31739446›Full record

ReviewJournal of clinical medicine2019

Lung Microbiome in Asthma: Current Perspectives.

Konstantinos Loverdos, Georgios Bellos, Louiza Kokolatou, Ioannis Vasileiadis, Evangelos Giamarellos, Matteo Pecchiari, Nikolaos Koulouris, Antonia Koutsoukou, Nikoletta Rovina

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05728385 (Impact of Modified Specific Carbohydrate Diet on Bronchial Asthma Control in Children), which is not on this map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05728385 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Impact of Modified Specific Carbohydrate Diet on Bronchial Asthma Control in Children

TypeinterventionalSponsorTanta UniversityRan2023 to 2024Enrolled60ConditionsAsthma in ChildrenArmsModified Specific carbohydrate diet for 3 months
3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Asthma occurrence in children and early life systemic antibiotic use: an incidence density study.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Article
  18. The Lung Microbiome: A New Frontier for Lung and Brain Disease.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Konstantinos LoverdosICU, 1st Department of Pulmonary Medicine, "Sotiria" Hospital; Athens School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Georgios BellosKoropi Academic Health Care Center, Koropi, 19400 Attica, Greece.
Louiza KokolatouKoropi Academic Health Care Center, Koropi, 19400 Attica, Greece.
Ioannis VasileiadisICU, 1st Department of Pulmonary Medicine, "Sotiria" Hospital; Athens School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Evangelos Giamarellos4th Department of Internal Medicine, Attikon University Hospital, 12462 Athens, Greece.
Matteo PecchiariDipartimento di Fisiopatologia e dei Trapianti, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0003-0513-9311
Nikolaos KoulourisICU, 1st Department of Pulmonary Medicine, "Sotiria" Hospital; Athens School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Antonia KoutsoukouICU, 1st Department of Pulmonary Medicine, "Sotiria" Hospital; Athens School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Nikoletta RovinaICU, 1st Department of Pulmonary Medicine, "Sotiria" Hospital; Athens School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0003-0138-5582

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing body of evidence implicates the human microbiome as a potentially influential player actively engaged in shaping the pathogenetic processes underlying the endotypes and phenotypes of chronic respiratory diseases, particularly of the airways. In this article, we specifically review current evidence on the characteristics of lung microbiome, and specifically the bacteriome, the modes of interaction between lung microbiota and host immune system, the role of the "lung-gut axis", and the functional effects thereof on asthma pathogenesis. We also attempt to explore the possibilities of therapeutic manipulation of the microbiome, aiming at the establishment of asthma prevention strategies and the optimization of asthma treatment.

Indexed as

asthmaimmune responsesinflammationmicrobiomepathogenesis

Identifiers

PMID31739446
PMCPMC6912699

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.