Evidence map›Paper›PMID 31739414›Full record

ArticleJournal of clinical medicine2019

Etiology of Minor Troponin Elevations in Patients with Atrial Fibrillation at Emergency Department-Tropo-AF Study.

Samuli Jaakkola, Tuomas Paana, Ilpo Nuotio, Tuomas O Kiviniemi, Jussi-Pekka Pouru, Pekka Porela, Fausto Biancari, K E Juhani Airaksinen

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Prevalence, Determinants and Clinical Significance of Cardiac Troponin-I Elevation among Individuals with Hypertensive Emergency: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022
    Article
  6. Article
  7. Cardiac Troponin Release After Endurance Exercise: Still Much to Learn.Journal of the American Heart Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Samuli JaakkolaHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.ORCID 0000-0001-5944-6814
Tuomas PaanaHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Ilpo NuotioHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Tuomas O KiviniemiHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Jussi-Pekka PouruHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.ORCID 0000-0002-5654-4344
Pekka PorelaHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.
Fausto BiancariHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.ORCID 0000-0001-5028-8186
K E Juhani AiraksinenHeart Center, Turku University Hospital and University of Turku, 20521 Turku, Finland.ORCID 0000-0002-0193-568X
University of Turku · FIBrigham and Women's Hospital · US

Funding

and State Clinical Research Fund (EVO) of Turku University Hospital, Turku, Finland N/AThe Finnish Foundation for Cardiovascular Research, Helsinki, Finland N/A
6 · The paper itself

Abstract

Patients with atrial fibrillation (AF) presenting to the emergency department (ED) often have elevated cardiac troponin T (TnT) levels without evidence of type 1 myocardial infarction. We sought to explore the causes and significance of minor TnT elevations in patients with AF at the ED. All patients with AF admitted to the ED of Turku University Hospital between 1 March, 2013 and 11 April, 2016, and at least two TnT measurements, were screened. Overall, 2911 patients with a maximum TnT of 100 ng/L during hospitalization were analyzed. TnT was between 15 and 100 ng/L in 2116 patients. The most common primary discharge diagnoses in this group were AF (18.1%), infection (18.3%), ischemic stroke/transient ischemic attack (10.7%), and heart failure (5.0%). Acute coronary syndrome (ACS) was equally uncommon both in patients with normal TnT and elevated TnT (4.4% vs. 4.5%). Age ≥75 years, low estimated glomerular filtration rate (eGFR), high C-reactive protein (CRP), and hemoglobin <10.0 g/dL, were the most important predictors of elevated TnT. Importantly, TnT elevation was a very frequent (>93%) finding in elderly (≥75 years) AF patients with either low eGFR or high CRP. In conclusion, minor TnT elevations carry limited diagnostic value in elderly AF patients with comorbidities.

Indexed as

acute coronary syndromeatrial fibrillationtroponin

Identifiers

PMID31739414
PMCPMC6912339
OpenAlexW2986071272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.