Evidence map›Paper›PMID 31739364›Full record

Observational studyAmerican journal of perinatology2020

Acute Kidney Injury is Associated with Poor Lung Outcomes in Infants Born ≥32 Weeks of Gestational Age.

Michelle C Starr, Louis Boohaker, Laurie C Eldredge, Shina Menon, Russell Griffin, Dennis Mayock, David Askenazi, Sangeeta Hingorani, Neonatal Kidney Collaborative

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in American journal of perinatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02443389 (Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02443389 completednot on this map

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates

Typeobservational_patient_registrySponsorUniversity of Alabama at BirminghamRan2015 to 2016Enrolled2,186ConditionsAcute Kidney Injury
3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Neonatal acute kidney injury: a case-based approach.Pediatric nephrology (Berlin, Germany) · 2021
    Review
  13. Pediatric acute kidney injury: new advances in the last decade.Kidney research and clinical practice · 2021
    Article
  14. Article
  15. Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2020
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michelle C StarrDivision of Pediatric Nephrology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.ORCID 0000-0001-9412-8950
Louis BoohakerDivision of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, Alabama.
Laurie C EldredgeDivision of Pulmonology, Department of Pediatrics, Seattle Children's Hospital and University of Washington, Seattle, Washington.
Shina MenonDivision of Nephrology, Department of Pediatrics, Seattle Children's Hospital and University of Washington, Seattle, Washington.
Russell GriffinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Dennis MayockDivision of Neonatology, Department of Pediatrics, University of Washington, Seattle, Washington.
David AskenaziDivision of Pediatric Nephrology, University of Alabama at Birmingham, Birmingham, Alabama.
Sangeeta HingoraniDivision of Nephrology, Department of Pediatrics, Seattle Children's Hospital and University of Washington, Seattle, Washington.
Neonatal Kidney Collaborative

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
Preterm Epo Neuroprotection Trial (PENUT Trial) CCCU01NS077953 · NINDS · UNIVERSITY OF WASHINGTON · PI JUUL, SANDRA E · 2013 to 2018
$10.7M
The University of Iowa Clinical and Translational Science AwardU54TR001356 · NCATS · UNIVERSITY OF IOWA · PI WINOKUR, PATRICIA · 2015 to 2016
$7.1M
Pediatric Nephrology Training ProgramT32DK007662 · NIDDK · UNIVERSITY OF WASHINGTON · PI HINGORANI, SANGEETA · 1991 to 2020
$5.5M
Recombinant Erythropoietin for Protection of Infant Renal Disease(REPAIReD)R01DK103608 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI ASKENAZI, DAVID JOSEPH, GOLDSTEIN, STUART L · 2014 to 2019
$3.0M
FDA HHS R01 FD005092NCATS NIH HHS U54 TR001356NCATS NIH HHS UL1 TR001417NCATS NIH HHS UL1 TR001449NIDDK NIH HHS R01 DK103608NIDDK NIH HHS T32 DK007662NINDS NIH HHS U01 NS077953
6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the association between acute kidney injury (AKI) and lung outcomes in infants born ≥32 weeks of gestational age (GA). STUDY

designSecondary analysis of infants ≥32 weeks of GA in the assessment of worldwide acute kidney injury epidemiology in neonates (AWAKEN) retrospective cohort (

resultsCLD occurred in 82/1,348 (6.1%) infants, while death occurred in 22/1,348 (1.6%); the composite of CLD/death occurred in 104/1,348 (7.7%). Infants with AKI had an almost five-fold increased odds of CLD/death, which remained after controlling for GA, maternal polyhydramnios, multiple gestations, 5-minute Apgar's score, intubation, and hypoxic-ischemic encephalopathy (adjusted odds ratio [OR] = 4.9, 95% confidence interval [CI]: 3.2-7.4;

conclusionAKI is associated with CLD/death and longer duration of respiratory support in infants born at ≥32 weeks of GA. Further prospective studies are needed to elucidate the pathophysiologic relationship.

Indexed as

Infant, Premature, DiseasesAcute Kidney InjuryChronic DiseaseFemaleHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalLogistic ModelsLung DiseasesMaleRespiration, ArtificialRetrospective StudiesRisk Factors

Identifiers

PMID31739364
PMCPMC7408289

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.