Evidence map›Paper›PMID 31739098›Full record

SynthesisProstaglandins, leukotrienes, and essential fatty acids2019

Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews.

Joseph R Hibbeln, Philip Spiller, J Thomas Brenna, Jean Golding, Bruce J Holub, William S Harris, Penny Kris-Etherton, Bill Lands, Sonja L Connor, Gary Myers and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Prostaglandins, leukotrienes, and essential fatty acids, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Neurodevelopmental Outcomes Associated with Early-Life Exposure to Heavy Metals: A Systematic Review.International journal of environmental research and public health · 2025
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  8. Prenatal Mercury Exposure and Neurodevelopment up to the Age of 5 Years: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  12. Nutrients · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joseph R HibbelnNational Institute on Alcohol Abuse and Alcoholism, NIH, USA. Electronic address: jhibbeln@mail.nih.gov.
Philip SpillerCenter for Food Safety and Applied Nutrition, USA.
J Thomas BrennaDell Pediatric Research Institute, Depts of Pediatrics, of Chemistry, and of Nutrition, University of Texas at Austin, TX, USA.
Jean GoldingPediatric and Perinatal Epidemiology, Population Health Sciences, University of Bristol, Bristol, UK.
Bruce J HolubDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
William S HarrisDepartment of Internal Medicine, University of South Dakota School of Medicine and OmegaQuant Analytics, LLC, Sioux Falls, SD, USA.
Penny Kris-EthertonDepartment of Nutritional Sciences, Penn State University, University Park, PA, USA.
Bill LandsAmerican Society for Nutrition, College Park, MD, USA.
Sonja L ConnorEndocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University, Portland, OR, USA.
Gary MyersNeurology, Pediatrics, and Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA.
J J StrainNutrition Innovation Centre for Food & Health, (NICHE), Ulster University, Coleraine, Northern Ireland, UK.
Michael A CrawfordDivision of Obstetrics and Gynaecology, Department of Surgery and Cancer, Imperial College London, UK.
Susan E CarlsonDepartment of Dietetics and Nutrition, University of Kansas Medical Center, Kansas City, KS, USA.

Funding

ESSENTIAL FATTY ACIDS IN PSYCHIATRIC DISORDERSZ01AA000115 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HIBBELN, JOSEPH R. · 2000 to 2008
$808k
Intramural NIH HHS Z01 AA000115Medical Research Council G1100226
6 · The paper itself

Abstract

Abundant data are now available to evaluate relationships between seafood consumption in pregnancy and childhood and neurocognitive development. We conducted two systematic reviews utilizing methodologies detailed by the Dietary Guidelines for Americans Scientific Advisory Committee 2020-2025. After reviewing 44 publications on 106,237 mother-offspring pairs and 25,960 children, our technical expert committee developed two conclusion statements that included the following: "Moderate and consistent evidence indicates that consumption of a wide range of amounts and types of commercially available seafood during pregnancy is associated with improved neurocognitive development of offspring as compared to eating no seafood. Overall, benefits to neurocognitive development began at the lowest amounts of seafood consumed (∼4 oz/wk) and continued through the highest amounts, above 12 oz/wk, some range up to >100 oz/wk.", "This evidence does not meet the criteria for "strong evidence" only due to a paucity of randomized controlled trials that may not be ethical or feasible to conduct for pregnancy" and "Moderate and consistent evidence indicates that consumption of >4 oz/wk and likely >12 oz/wk of seafood during childhood has beneficial associations with neurocognitive outcomes." No net adverse neurocognitive outcomes were reported among offspring at the highest ranges of seafood intakes despite associated increases in mercury exposures. Data are insufficient for conclusive statements regarding lactation, optimal amounts, categories or specific species characterized by mercury content and neurocognitive development; although there is some evidence that dark/oily seafood may be more beneficial. Research was conducted in healthy women and children and is generalizable to US populations. Assessment of seafood as a whole food integrates inherently integrates any adverse effects from neurotoxicants, if any, and benefits to neurocognition from omega-3 fats, as well as other nutrients critical to optimal neurological development. Understanding of the effects of seafood consumption on neurocognition can have significant public health implications.

Indexed as

ChildChild DevelopmentFatty Acids, Omega-3FemaleHumansMental HealthMental ProcessesNutrition AssessmentPregnancyPrenatal Nutritional Physiological PhenomenaSeafoodFatty Acids, Omega-3

Identifiers

PMID31739098
PMCPMC6924512

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.